Is Red 6 Lake (CI 15850) safe in cosmetics?
Red 6 Lake (CI 15850) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Red 6 Lake (CI 15850)
Also known as: Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, C.I. Pigment Red 57, disodium salt, C.I. 15850, D&c red no.6, EINECS 227-497-9 (+7 more)
INCI: RED 6 LAKE
Red 6 Lake (CI 15850) (CAS 5858-81-1) is a cosmetic colorant functioning as Colorant. Reported NOAEL =150 mg/kg bw/day in rat (SCCNFP Opinion); EU Regulation 1223/2009 status: permitted, max 0.4%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Colorant
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.4%
US US Status
permitted
US Notes
Deferred evaluation - safety assessed by FDA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Red 6 Lake (CI 15850).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Red 6 Lake (CI 15850). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS Opinion |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS Opinion |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,4 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,4 %
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.007% | - | - | SCCS/1411/11 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Red 6 Lake (CI 15850) — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Red 6 Lake (CI 15850) by CAS number or substance name.
Studies
28
Lowest NOAEL
0
Highest NOAEL
150
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.007% | SCCS PDF direct extraction | - |
Known Synonyms
Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate
C.I. Pigment Red 57, disodium salt
C.I. 15850
D&c red no.6
EINECS 227-497-9
Japan Red 201
Cerven pigment 57
UNII-481744AI4O
FD&C Red No. 6
disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
EC No.: 227-497-9
227-497-9
Chemical Function
Pigment
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
pharmaceutical
Personal care
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D&C Red 6 (Lithol Rubine B)
Food Category
colorant
Frequently Asked Questions
Is Red 6 Lake (CI 15850) allowed in the EU?
Red 6 Lake (CI 15850) EU regulatory status: permitted. Maximum allowed concentration: 0.4%. This is based on EU Regulation 1223/2009 and its amendments.
What does Red 6 Lake (CI 15850) do in cosmetics?
Red 6 Lake (CI 15850) functions as: Colorant. It is classified as a Colorant in our database. CAS number: 5858-81-1.
What is the NOAEL for Red 6 Lake (CI 15850)?
The NOAEL (No Observed Adverse Effect Level) for Red 6 Lake (CI 15850) is =150 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is Red 6 Lake (CI 15850) used outside cosmetics?
Red 6 Lake (CI 15850) also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Red 6 Lake (CI 15850) compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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