Is CI 15850 Red 7 Lake safe in cosmetics?
CI 15850 Red 7 Lake has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
CI 15850 Red 7 Lake
Also known as: Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, C.I. Pigment Red 57, disodium salt, C.I. 15850, D&c red no.6, EINECS 227-497-9 (+7 more)
INCI: CI 15850
CI 15850 Red 7 Lake (CAS 5858-81-1) is a cosmetic colorant functioning as Colorant. Reported NOAEL =150 mg/kg bw/day in rat (SCCNFP Opinion); EU Regulation 1223/2009 status: permitted, max 10%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Colorant
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
10%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 15850 Red 7 Lake.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 15850 Red 7 Lake. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP Opinion |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP Opinion |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS Opinion |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS Opinion |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,4 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,4 %
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.007% | - | - | SCCS/1411/11 |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Lipstick | 1–10 | 20 | CIR Safety Assessment |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for CI 15850 Red 7 Lake — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 15850 Red 7 Lake by CAS number or substance name.
Studies
28
Lowest NOAEL
0
Highest NOAEL
150
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.007% | SCCS PDF direct extraction | - |
Known Synonyms
Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate
C.I. Pigment Red 57, disodium salt
C.I. 15850
D&c red no.6
EINECS 227-497-9
Japan Red 201
Cerven pigment 57
UNII-481744AI4O
FD&C Red No. 6
disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
EC No.: 227-497-9
227-497-9
Chemical Function
Pigment
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
pharmaceutical
Personal care
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D&C Red 6 (Lithol Rubine B)
Food Category
colorant
Frequently Asked Questions
Is CI 15850 Red 7 Lake allowed in the EU?
CI 15850 Red 7 Lake EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 15850 Red 7 Lake do in cosmetics?
CI 15850 Red 7 Lake functions as: Colorant. It is classified as a Colorant in our database. CAS number: 5858-81-1.
What is the NOAEL for CI 15850 Red 7 Lake?
The NOAEL (No Observed Adverse Effect Level) for CI 15850 Red 7 Lake is =150 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is CI 15850 Red 7 Lake used outside cosmetics?
CI 15850 Red 7 Lake also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 15850 Red 7 Lake compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
CI 77491 (Red Iron Oxide)
EXCELLENT
Same category
Colorant
CI 77492 (Yellow Iron Oxide)
EXCELLENT
Same category
Colorant
CI 77499 (Black Iron Oxide)
EXCELLENT
Same category
Colorant
Calcium Aluminum Borosilicate
EXCELLENT
Same category
colorant, opacifier, pearlescent agent
Ferric Ferrocyanide
EXCELLENT
Same category
Colorant; Prussian Blue pigment
Ferric Ferrocyanide (Prussian Blue)
EXCELLENT
Same category
Colorant (blue)
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
CI 15630
GOOD
Chemical family
Colorant (red)
CI 15850
GOOD
Chemical family
Colorant (red)
D&C Red No. 6
GOOD
Chemical family
colorant
Is CI 15850 Red 7 Lake in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 15850 Red 7 Lake in your formulation.