Good Cosmetic Ingredient NOAEL Data Sensitization Data

Rosmarinus Officinalis Leaf Oil

INCI: ROSMARINUS OFFICINALIS LEAF OIL

CAS Number
84604-14-8
Function
Fragrance, Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS under 21 CFR 182.10 (spice) and 182.20 (essential oil). 474 formulations reported in 2014 VCRP data. No specific cosmetic restrictions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Rosmarinus Officinalis Leaf Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 130 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 130 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 200 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 130 mg/kg bw/day oral rat Developmental COSMOS_DB
dose_tested 130 mg/kg bw/day oral rat Developmental COSMOS_DB
dose_tested 1500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Sensitization Profile

Contact sensitization data for Rosmarinus Officinalis Leaf Oil based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
terpene-hydroperoxide-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: IFRA

Expert Verdict

Rosmarinus Officinalis Leaf Oil is a widely used fragrance and conditioning agent with good safety profile when formulated to be non-sensitizing; however, allergen audit is required due to EU Reg. 2023/1545 expanding the allergen list with a 31 July 2026 compliance deadline.

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Concern Level: Low

Regulatory Flags

ALLERGEN eu_children_restricted fda_food_additive

Frequently Asked Questions

Is Rosmarinus Officinalis Leaf Oil safe in cosmetics?

Rosmarinus Officinalis Leaf Oil is a widely used fragrance and conditioning agent with good safety profile when formulated to be non-sensitizing; however, allergen audit is required due to EU Reg. 2023/1545 expanding the allergen list with a 31 July 2026 compliance deadline. The EU classifies Rosmarinus Officinalis Leaf Oil as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is Rosmarinus Officinalis Leaf Oil allowed in the EU?

Rosmarinus Officinalis Leaf Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Rosmarinus Officinalis Leaf Oil do in cosmetics?

Rosmarinus Officinalis Leaf Oil functions as: Fragrance, Skin Conditioning. It is classified as a Cosmetic Ingredient in our database. CAS number: 84604-14-8.

What is the Margin of Safety for Rosmarinus Officinalis Leaf Oil?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Rosmarinus Officinalis Leaf Oil?

The NOAEL (No Observed Adverse Effect Level) for Rosmarinus Officinalis Leaf Oil is 200 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

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