Is Silybum Marianum Seed Extract safe in cosmetics?
Silybum Marianum Seed Extract has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Silybum Marianum Seed Extract
Also known as: Silybum marianum extracts, Flavopherol, EINECS 283-298-7, Lady's thistle (Silybum marianum L. Gaertner), Milk thistle extracts
INCI: SILYBUM MARIANUM SEED EXTRACT
Silybum Marianum Seed Extract (CAS 84604-20-6) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 84604-20-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Antioxidant
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; well-documented dietary supplement history supports safety profile
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silybum Marianum Seed Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Silybum Marianum Seed Extract.
Regulatory Flags
plant-extract
Known Synonyms
Silybum marianum extracts
Flavopherol
EINECS 283-298-7
Lady's thistle (Silybum marianum L. Gaertner)
Milk thistle extracts
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
582
Frequently Asked Questions
Is Silybum Marianum Seed Extract allowed in the EU?
Silybum Marianum Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Silybum Marianum Seed Extract do in cosmetics?
Silybum Marianum Seed Extract functions as: Skin Conditioning, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 84604-20-6.
Is Silybum Marianum Seed Extract used outside cosmetics?
Silybum Marianum Seed Extract also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Silybum Marianum Seed Extract compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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