Is Silybum Marianum Seed Oil safe in cosmetics?
Silybum Marianum Seed Oil has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Emollient
Silybum Marianum Seed Oil
Also known as: Silybum marianum extracts, Flavopherol, EINECS 283-298-7, Lady's thistle (Silybum marianum L. Gaertner), Milk thistle extracts
INCI: SILYBUM MARIANUM SEED OIL
Silybum Marianum Seed Oil (CAS 84604-20-6) is a cosmetic emollient functioning as Skin conditioning, emollient, occlusive, moisturizing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 84604-20-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, emollient, occlusive, moisturizing
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (2017) concluded Silybum Marianum Seed Oil is safe as used in cosmetics as part of a 244-oil class review. No FDA restrictions on cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silybum Marianum Seed Oil.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Silybum Marianum Seed Oil.
Regulatory Flags
asteraceae-cross-reactivity
oxidation-risk
high-pufa
Known Synonyms
Silybum marianum extracts
Flavopherol
EINECS 283-298-7
Lady's thistle (Silybum marianum L. Gaertner)
Milk thistle extracts
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
582
Frequently Asked Questions
Is Silybum Marianum Seed Oil allowed in the EU?
Silybum Marianum Seed Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Silybum Marianum Seed Oil do in cosmetics?
Silybum Marianum Seed Oil functions as: Skin conditioning, emollient, occlusive, moisturizing. It is classified as a Emollient in our database. CAS number: 84604-20-6.
Is Silybum Marianum Seed Oil used outside cosmetics?
Silybum Marianum Seed Oil also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Silybum Marianum Seed Oil compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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