Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Hypochlorite. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5075 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 393 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 346 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 130 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 5075 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
🔴 DO NOT FORMULATE into cosmetic products. EU Annex II prohibited. Strong oxidizer; corrosive; incompatible with most cosmetic ingredients; reacts with organics to form chlorinated byproducts. Sometimes confused with hypochlorous acid (HOCl) — they are chemically and regulatorily distinct.
Regulatory Flags
Frequently Asked Questions
Is Sodium Hypochlorite safe in cosmetics?
🔴 DO NOT FORMULATE into cosmetic products. EU Annex II prohibited. Strong oxidizer; corrosive; incompatible with most cosmetic ingredients; reacts with organics to form chlorinated byproducts. Sometimes confused with hypochlorous acid (HOCl) — they are chemically and regulatorily distinct. The EU classifies Sodium Hypochlorite as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Hypochlorite allowed in the EU?
Sodium Hypochlorite EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Hypochlorite do in cosmetics?
Sodium Hypochlorite functions as: Bleaching; Oxidizing; Antimicrobial (primarily industrial/household biocide). It is classified as a cosmetic ingredient in our database. CAS number: 7681-52-9.
What is the Margin of Safety for Sodium Hypochlorite?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Hypochlorite?
The NOAEL (No Observed Adverse Effect Level) for Sodium Hypochlorite is 5075 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Sodium Hypochlorite classified as hazardous under GHS?
Sodium Hypochlorite carries a GHS signal word of "WARNING". Hazard statements: May be osive to metals Causes skin and eye irritation Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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