Is Sodium Isethionate safe in cosmetics?
Sodium Isethionate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Sodium Isethionate
Also known as: EINECS 216-343-6, NSC 124283, Sodium beta-hydroxyethanesulfonate, Sodium 2-hydroxyethyl sulfonate, UNII-3R36J71C17
INCI: SODIUM ISETHIONATE
Sodium Isethionate (CAS 1562-00-1) is a cosmetic cosmetic ingredient functioning as Surfactant precursor; used in bath soaps/detergents (the sodium salt of. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1562-00-1 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant precursor; used in bath soaps/detergents (the sodium salt of 2-hydroxyethanesulfonic acid)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
sodium 2-hydroxyethanesulfonate
InChIKey
LADXKQRVAFSPTR-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Reported in 77 cosmetic products (VCRP); used at 0.1–5% concentrations; safe per CIR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Isethionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Sodium Isethionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =426 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Isethionate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Cleaning agent
No specific technical function
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Isethionate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Isethionate by CAS number or substance name.
Studies
2
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
426 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 216-343-6
NSC 124283
Sodium beta-hydroxyethanesulfonate
Sodium 2-hydroxyethyl sulfonate
UNII-3R36J71C17
Chemical Function
Anti-static agent
Softener and conditioner
Cleaning agent
No specific technical function
Surfactant (surface active agent)
Regulatory Lists
CEDI
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL172191
Frequently Asked Questions
Is Sodium Isethionate allowed in the EU?
Sodium Isethionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Isethionate do in cosmetics?
Sodium Isethionate functions as: Surfactant precursor; used in bath soaps/detergents (the sodium salt of 2-hydroxyethanesulfonic acid). It is classified as a cosmetic ingredient in our database. CAS number: 1562-00-1.
What is the NOAEL for Sodium Isethionate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Isethionate is =200 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Isethionate used outside cosmetics?
Sodium Isethionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Isethionate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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