Moderate Cosmetic Ingredient NOAEL Data

Steartrimonium Chloride

INCI: STEARTRIMONIUM CHLORIDE

CAS Number
112-03-8
Function
Antistatic, hair conditioning, preservative, surfactant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR-assessed โ€” safe as used in cosmetics at reported concentrations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Steartrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10 mg/kg bw/day dermal code:3484 dermal REACH
NOEL ca.100 mg/kg bw/day oral rat oral REACH
NOAEL ca.113 mg/kg bw/day oral rat oral REACH
NOAEL 10 mg/kg bw/day dermal code:3484 dermal REACH
NOAEL ca.113 mg/kg bw/day oral rat oral REACH
NOAEL 45 mg/kg bw/day oral rat oral REACH
NOEL ca.100 mg/kg bw/day oral rat oral REACH
NOAEL 45 mg/kg bw/day oral rat oral REACH

Expert Verdict

EU Annex III โ€” subject to maximum concentration and possible product-type restrictions. Potential irritant at high concentrations. Aquatic toxicity concern (cationic surfactant)

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Concern Level: High

Regulatory Flags

preservative

Frequently Asked Questions

Is Steartrimonium Chloride safe in cosmetics?

EU Annex III โ€” subject to maximum concentration and possible product-type restrictions. Potential irritant at high concentrations. Aquatic toxicity concern (cationic surfactant) The EU classifies Steartrimonium Chloride as "restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.

Is Steartrimonium Chloride allowed in the EU?

Steartrimonium Chloride EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Steartrimonium Chloride do in cosmetics?

Steartrimonium Chloride functions as: Antistatic, hair conditioning, preservative, surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 112-03-8.

What is the Margin of Safety for Steartrimonium Chloride?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Steartrimonium Chloride?

The NOAEL (No Observed Adverse Effect Level) for Steartrimonium Chloride is 10 mg/kg bw/day based on a dermal study via dermal route in code:3484. A total of 8 study endpoints are available. Source: REACH.

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