Is Steartrimonium Chloride safe in cosmetics?
Steartrimonium Chloride has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Steartrimonium Chloride
Also known as: 1-Octadecanaminium, N,N,N-trimethyl-, chloride, EINECS 203-929-1, Monostearyl trimethyl ammonium chloride, Quaternium-10, UNII-CZ70647U92
INCI: STEARTRIMONIUM CHLORIDE
Steartrimonium Chloride (CAS 112-03-8) is a cosmetic cosmetic ingredient functioning as Antistatic, hair conditioning, preservative, surfactant. NOAEL 45 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 112-03-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Steartrimonium Chloride is classified GHS Danger (H302, H311, H312, H314, H318, H400, H410) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic, hair conditioning, preservative, surfactant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
trimethyl(octadecyl)azanium chloride
InChIKey
VBIIFPGSPJYLRR-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
CIR-assessed — safe as used in cosmetics at reported concentrations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Steartrimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Steartrimonium Chloride across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
hair_conditioning
{"cas_number": "112-03-8", "ingredient_class": "cationic_conditioner", "chemical_type": "quaternary_ammonium", "charge_density_meq_g": "high", "substantivity_to_hair": "excellent", "deposition_from_shampoo": "no", "deposition_from_conditioner": "yes", "conditioning_mechanism": "electrostatic", "hair_penetration": "cuticle", "molecular_weight_effect_on_penetration": "C18_quaternary", "wet_combing_f…
sensory
{"silky": "waxy", "smooth, glides easily": "smooth, conditioning", "dry-touch, non-greasy": "soft, manageable", "instant": "moderate", "low": "medium", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "1.40": "1.45", "transparent": "opaque", "colorless": "white", "excellent": "fair", "light": "medium", "synthetic": "synthetic"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135)
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Emulsifier
Preservative
Softener and conditioner
Stabilizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Steartrimonium Chloride.
Regulatory Flags
preservative
Known Synonyms
1-Octadecanaminium, N,N,N-trimethyl-, chloride
EINECS 203-929-1
Monostearyl trimethyl ammonium chloride
Quaternium-10
UNII-CZ70647U92
Chemical Function
Preservative
Anti-static agent
Softener and conditioner
Stabilizing agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRIMETHYL-OCTADECYL-AMMONIUM CHLORIDE
ChEMBL ID
CHEMBL118745
Frequently Asked Questions
Is Steartrimonium Chloride allowed in the EU?
Steartrimonium Chloride EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Steartrimonium Chloride do in cosmetics?
Steartrimonium Chloride functions as: Antistatic, hair conditioning, preservative, surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 112-03-8.
Is Steartrimonium Chloride used outside cosmetics?
Steartrimonium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Steartrimonium Chloride have different safety status in cosmetics vs industrial chemicals?
Steartrimonium Chloride is classified GHS Danger (H302, H311, H312, H314, H318, H400, H410) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Steartrimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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