Sucrose Acetate Isobutyrate
INCI: SUCROSE ACETATE ISOBUTYRATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sucrose Acetate Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2592 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2247 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2226 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 450 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 2707 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1290 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 375 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 190 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Expert Verdict
Lead impurities must be ≤1 ppm; purity ≥98.8%. At very high oral doses in dogs, elevated serum alkaline phosphatase and BSP retention were observed (reversible). Not a concern at cosmetic use levels
Regulatory Flags
Frequently Asked Questions
Is Sucrose Acetate Isobutyrate safe in cosmetics?
Lead impurities must be ≤1 ppm; purity ≥98.8%. At very high oral doses in dogs, elevated serum alkaline phosphatase and BSP retention were observed (reversible). Not a concern at cosmetic use levels The EU classifies Sucrose Acetate Isobutyrate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Sucrose Acetate Isobutyrate allowed in the EU?
Sucrose Acetate Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sucrose Acetate Isobutyrate do in cosmetics?
Sucrose Acetate Isobutyrate functions as: Plasticizer, film former, viscosity controlling agent. It is classified as a cosmetic ingredient in our database. CAS number: 126-13-6.
What is the Margin of Safety for Sucrose Acetate Isobutyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sucrose Acetate Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Sucrose Acetate Isobutyrate is 2592 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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