Regulatory Status
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Safety Data
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Expert Verdict
CRITICAL: Strong in vitro mutagen (Ames+, clastogenic in chromosomal aberration assay); extreme sensitizer; strongly irritating to eyes (HCl form); SCCNFP opinion = insufficient safety data; orange/red staining of skin and organs; NOEL only 5 mg/kg/day oral; not recommended without resolution of genotoxicity concerns
Regulatory Flags
Frequently Asked Questions
Is Tetrahydro-6-nitroquinoxaline safe in cosmetics?
CRITICAL: Strong in vitro mutagen (Ames+, clastogenic in chromosomal aberration assay); extreme sensitizer; strongly irritating to eyes (HCl form); SCCNFP opinion = insufficient safety data; orange/red staining of skin and organs; NOEL only 5 mg/kg/day oral; not recommended without resolution of genotoxicity concerns The EU classifies Tetrahydro-6-nitroquinoxaline as "permitted". Safety rating: POOR.
Is Tetrahydro-6-nitroquinoxaline allowed in the EU?
Tetrahydro-6-nitroquinoxaline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydro-6-nitroquinoxaline do in cosmetics?
Tetrahydro-6-nitroquinoxaline functions as: Hair dyeing, light stabilizer — used as semi-permanent/direct hair dye at ≤1% concentration. It is classified as a cosmetic ingredient in our database. CAS number: 41959-35-7 (free base); 158006-54-3 (hydrochloride).
What is the Margin of Safety for Tetrahydro-6-nitroquinoxaline?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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