Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®)
INCI: ACETYL HEXAMETHYL INDAN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Polycyclic musk – environmental persistence and bioaccumulation; detected in aquatic environments and human tissues; SCCS monitoring class
Regulatory Flags
Frequently Asked Questions
Is Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) safe in cosmetics?
Polycyclic musk – environmental persistence and bioaccumulation; detected in aquatic environments and human tissues; SCCS monitoring class The EU classifies Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) allowed in the EU?
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) do in cosmetics?
Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) functions as: Fragrance – polycyclic musk, sweet musky note. It is classified as a cosmetic ingredient in our database. CAS number: 15323-35-0.
What is the Margin of Safety for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®)?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) is 5 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check Tetrahydro-hexamethyl-as-indacen-3-one (Phantolide®) compliance across multiple jurisdictions:
Related Ingredients
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