Is Thiamine Diphosphate safe in cosmetics?
Thiamine Diphosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Thiamine Diphosphate
Also known as: Bioxylasi, EINECS 205-836-1, Thiaminediphosphate, Thiaminepyrophosphate, Thiaminpyrophosphate (+14 more)
INCI: THIAMINE DIPHOSPHATE
Thiamine Diphosphate (CAS 154-87-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 154-87-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate chloride
InChIKey
YXVCLPJQTZXJLH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; also used as a dietary supplement ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiamine Diphosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Thiamine Diphosphate.
Known Synonyms
Bioxylasi
EINECS 205-836-1
Thiaminediphosphate
Thiaminepyrophosphate
Thiaminpyrophosphate
Cocarboxylasum
B-Carbossilasi
Cocarvit
Coenzyme-B
Coneurina
Cothiamine
Magnesiocarbina
Stadion
Co-carboxylase
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium chloride
Coenzymate
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, P,P'-dioxide
thiamine diphosphate chloride
thiamine(1+) diphosphate chloride
Chemical Function
Softener and conditioner
Regulatory Lists
Europe; supplements
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2104121
Frequently Asked Questions
Is Thiamine Diphosphate allowed in the EU?
Thiamine Diphosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiamine Diphosphate do in cosmetics?
Thiamine Diphosphate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 154-87-0.
Is Thiamine Diphosphate used outside cosmetics?
Thiamine Diphosphate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Thiamine Diphosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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THIMEROSAL
Moderate
Browse nearby
Preservative
THYMUS LINEARIS LEAF/(ANGELICA GLAUCA/BERGENIA CILIATA) ROOT/PRINSEPIA UTILIS SEED EXTRACT
Good
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Skin Conditioning
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