Poor Cosmetic Ingredient GHS Classified

Toluene-2,6-Diamine

INCI: TOLUENE-2,6-DIAMINE

CAS Number
823-40-5
Function
Oxidative hair dye intermediate
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not commonly used; falls under coal tar hair dye provisions if used

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

๐Ÿšซ Prohibited in EU cosmetics (Annex II); mutagenicity concerns; no safety dossier submitted to SCCS; do not formulate with this isomer

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Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Toluene-2,6-Diamine safe in cosmetics?

๐Ÿšซ Prohibited in EU cosmetics (Annex II); mutagenicity concerns; no safety dossier submitted to SCCS; do not formulate with this isomer The EU classifies Toluene-2,6-Diamine as "prohibited". Safety rating: POOR.

Is Toluene-2,6-Diamine allowed in the EU?

Toluene-2,6-Diamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Toluene-2,6-Diamine do in cosmetics?

Toluene-2,6-Diamine functions as: Oxidative hair dye intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 823-40-5.

What is the Margin of Safety for Toluene-2,6-Diamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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