Is Toluene-2,6-Diamine safe in cosmetics?
Toluene-2,6-Diamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Toluene-2,6-Diamine
Also known as: 1,3-Benzenediamine, 2-methyl-, 3-13-00-00291, BRN 2079476, NSC 147490, o-Toluene diamine (+11 more)
INCI: TOLUENE-2,6-DIAMINE
Toluene-2,6-Diamine (CAS 823-40-5) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye intermediate. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 823-40-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Toluene-2,6-Diamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H341, H411, H315, H319, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Oxidative hair dye intermediate
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-methylbenzene-1,3-diamine
InChIKey
RLYCRLGLCUXUPO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not commonly used; falls under coal tar hair dye provisions if used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Toluene-2,6-Diamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Health HazardHarmful / IrritantEnvironmental Hazard
Hazard Class and Category
Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2
Hazard Statements
- H341 Suspected of causing genetic defects
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H317 May cause an allergic skin reaction
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 413
(EC) 2009/1223
CMR: Mutagenic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0340
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
In human beings, as in animals, diaminotoluenes are considered to be irritants for the mucous membranes and skin, and to lead to conjunctivitis and corneal opacities. ... In the case of ingestion of massive amounts, nausea, vomiting, and diarrhea would occur, with the possible production of methemoglobinemia. /Diaminotoluene/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Toluene-2,6-Diamine.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
1,3-Benzenediamine, 2-methyl-
3-13-00-00291
BRN 2079476
NSC 147490
o-Toluene diamine
Toluene, 2,6-diamino-
UNII-H838Q10551
2,6-DAT
2,6-diamino-1-methylbenzene
2,6-toluylenediamine
2,6-tolylenediamine
2-methyl-1,3-benzenediamine
2-methyl-1,3-phenylenediamine
2-methyl-m-phenylenediamine
EINECS 212-513-9
2,6-diaminotoluene
Chemical Function
Dye
Regulatory Lists
detected; Europe; Toys and children's products
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1489438
Frequently Asked Questions
Is Toluene-2,6-Diamine allowed in the EU?
Toluene-2,6-Diamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Toluene-2,6-Diamine do in cosmetics?
Toluene-2,6-Diamine functions as: Oxidative hair dye intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 823-40-5.
Is Toluene-2,6-Diamine used outside cosmetics?
Toluene-2,6-Diamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Toluene-2,6-Diamine have different safety status in cosmetics vs industrial chemicals?
Toluene-2,6-Diamine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H341, H411, H315, H319, H335).
Compliance Tools
Check Toluene-2,6-Diamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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TRAMETES VERSICOLOR EXTRACT
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