Good Cosmetic Ingredient NOAEL Data

Tribenzoin

INCI: TRIBENZOIN

CAS Number
614-33-5
Function
Fragrance ingredient, skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Tribenzoin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2571 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Functions as fragrance โ€” must comply with IFRA standards if used for scent; requires allergen declaration assessment under EU fragrance disclosure rules

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component fda_food_additive

Frequently Asked Questions

Is Tribenzoin safe in cosmetics?

Functions as fragrance โ€” must comply with IFRA standards if used for scent; requires allergen declaration assessment under EU fragrance disclosure rules The EU classifies Tribenzoin as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Tribenzoin allowed in the EU?

Tribenzoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tribenzoin do in cosmetics?

Tribenzoin functions as: Fragrance ingredient, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 614-33-5.

What is the Margin of Safety for Tribenzoin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tribenzoin?

The NOAEL (No Observed Adverse Effect Level) for Tribenzoin is 2571 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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