Is Ethyl Nicotinate safe in cosmetics?
Ethyl Nicotinate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Ethyl Nicotinate
Also known as: Ethylnicotinate, 3-Pyridinecarboxylic acid, ethyl ester, 3-Carbethoxypyridine, EINECS 210-370-7, 3-(Ethoxycarbonyl)pyridine (+12 more)
INCI: ETHYL NICOTINATE
Ethyl Nicotinate (CAS 614-18-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (vasodilator / rubefacient). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 614-18-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (vasodilator / rubefacient)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
ethyl pyridine-3-carboxylate
InChIKey
XBLVHTDFJBKJLG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no specific CFR prohibition; however, vasodilatory action could trigger FDA drug-claim scrutiny if marketed with efficacy claims
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Nicotinate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 151.2
Log Kow: 1.41
Log Kp: -3.1079053973095196
Log Jmax: -6.539703673242524
Source: Roberts_Cheruvu_Mendeley_2022
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (1)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Nicotinate.
Known Synonyms
Ethylnicotinate
3-Pyridinecarboxylic acid, ethyl ester
3-Carbethoxypyridine
EINECS 210-370-7
3-(Ethoxycarbonyl)pyridine
Ethyl 3-pyridinecarboxylate
Ethyl-nicotinate
Ignicut
Ignocut
Mucotherm
Nicaethan
Nicotinic acid,ethyl ester
Nikethan
Nikithan
NSC 8872
beta-Pyridinecarboxylic acid ethyl ester
UNII-NIJ3H353YH
Chemical Function
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHYL NICOTINATE
ChEMBL ID
CHEMBL2251611
Frequently Asked Questions
Is Ethyl Nicotinate allowed in the EU?
Ethyl Nicotinate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Nicotinate do in cosmetics?
Ethyl Nicotinate functions as: Skin conditioning agent (vasodilator / rubefacient). It is classified as a cosmetic ingredient in our database. CAS number: 614-18-6.
Is Ethyl Nicotinate used outside cosmetics?
Ethyl Nicotinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Nicotinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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