Is Undecylenoyl Glycine safe in cosmetics?
Undecylenoyl Glycine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Undecylenoyl Glycine
Also known as: UNII-4D20464K2J
INCI: UNDECYLENOYL GLYCINE
Undecylenoyl Glycine (CAS 54301-26-7) is a cosmetic surfactant functioning as Cleansing, Hair Conditioning, Surfactant, Antimicrobial, Deodorant Active. Reported NOAEL =150 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 54301-26-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Undecylenoyl Glycine is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Cleansing, Hair Conditioning, Surfactant, Antimicrobial, Deodorant Active
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(undec-10-enoylamino)acetic acid
InChIKey
ZROLMAVYZOMHRS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions. CIR grouped with 115 amino acid alkyl amides; no dedicated data.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Undecylenoyl Glycine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Undecylenoyl Glycine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =200 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =450 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "25353-73-5", "anti_acne_mechanism": "sebum_regulation/antibacterial", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "non_inflammatory", "p_acnes_mic_ug_per_ml": ">500", "sebum_reduction_pct_clinical": "20-30", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_funct…
preservative
{"preservative_class": "Amino acid derivative", "antimicrobial_spectrum_bacteria_gp": "Moderate", "antimicrobial_spectrum_bacteria_gn": "Moderate", "antimicrobial_spectrum_yeast": "Yes", "antimicrobial_spectrum_mold": "Yes", "mic_staph_aureus_ppm": "800", "mic_e_coli_ppm": "900", "mic_pseudomonas_ppm": "1100", "mic_candida_albicans_ppm": "1500", "mic_aspergillus_niger_ppm": "2100", "challenge_test…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Undecylenoyl Glycine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Undecylenoyl Glycine by CAS number or substance name.
Studies
3
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
450 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
UNII-4D20464K2J
Chemical Function
Surfactant (surface active agent)
Cleaning agent
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Undecylenoyl Glycine allowed in the EU?
Undecylenoyl Glycine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Undecylenoyl Glycine do in cosmetics?
Undecylenoyl Glycine functions as: Cleansing, Hair Conditioning, Surfactant, Antimicrobial, Deodorant Active. It is classified as a Surfactant in our database. CAS number: 54301-26-7.
What is the NOAEL for Undecylenoyl Glycine?
The NOAEL (No Observed Adverse Effect Level) for Undecylenoyl Glycine is =150 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Undecylenoyl Glycine used outside cosmetics?
Undecylenoyl Glycine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Undecylenoyl Glycine have different safety status in cosmetics vs industrial chemicals?
Undecylenoyl Glycine is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Undecylenoyl Glycine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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