Is Uracil safe in cosmetics?
Uracil has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
Uracil
Also known as: EINECS 200-621-9, UNII-56HH86ZVCT, 1,2,3,4-tetrahydropyrimidine-2,4-dione, Pirod, Pyrod (+2 more)
INCI: URACIL
Uracil (CAS 66-22-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, hair conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 66-22-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, hair conditioning agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1H-pyrimidine-2,4-dione
InChIKey
ISAKRJDGNUQOIC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted as a cosmetic ingredient. Note: 5-Fluorouracil (a fluorinated derivative) is an FDA-approved drug — uracil itself is not classified as a drug
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Uracil.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Uracil.
Known Synonyms
EINECS 200-621-9
UNII-56HH86ZVCT
1,2,3,4-tetrahydropyrimidine-2,4-dione
Pirod
Pyrod
Ura
Urazil
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
URACIL
ChEMBL ID
CHEMBL566
Max Phase
3
Adverse Event Associations
7
Frequently Asked Questions
Is Uracil allowed in the EU?
Uracil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Uracil do in cosmetics?
Uracil functions as: Skin conditioning agent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 66-22-8.
Is Uracil used outside cosmetics?
Uracil also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Uracil compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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