Uracil

INCI: URACIL

CAS Number
66-22-8
Function
Skin conditioning agent, hair conditioning agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted as a cosmetic ingredient. Note: 5-Fluorouracil (a fluorinated derivative) is an FDA-approved drug โ€” uracil itself is not classified as a drug

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Must not be confused with 5-fluorouracil (5-FU), which is cytotoxic. Ensure supplier CoA confirms absence of fluorinated impurities. Very limited cosmetic use data โ€” rare in finished formulations

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Concern Level: Moderate

Frequently Asked Questions

Is Uracil safe in cosmetics?

Must not be confused with 5-fluorouracil (5-FU), which is cytotoxic. Ensure supplier CoA confirms absence of fluorinated impurities. Very limited cosmetic use data โ€” rare in finished formulations The EU classifies Uracil as "permitted". Safety rating: GOOD.

Is Uracil allowed in the EU?

Uracil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Uracil do in cosmetics?

Uracil functions as: Skin conditioning agent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 66-22-8.

What is the Margin of Safety for Uracil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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