Urocanic Acid

INCI: UROCANIC ACID

CAS Number
104-98-3
Function
UV absorber / UV filter, skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not an FDA-approved OTC sunscreen active; not in FDA's sunscreen monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Immunosuppression risk: cis-urocanic acid (UV-induced photoisomer) suppresses cutaneous immune responses and may promote photocarcinogenesis; banned in Canada as cosmetic ingredient ; ethyl urocanate derivative also prohibited in Canada; not approved as UV filter in EU or US

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Concern Level: High

Frequently Asked Questions

Is Urocanic Acid safe in cosmetics?

Immunosuppression risk: cis-urocanic acid (UV-induced photoisomer) suppresses cutaneous immune responses and may promote photocarcinogenesis; banned in Canada as cosmetic ingredient ; ethyl urocanate derivative also prohibited in Canada; not approved as UV filter in EU or US The EU classifies Urocanic Acid as "restricted". Safety rating: MODERATE.

Is Urocanic Acid allowed in the EU?

Urocanic Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Urocanic Acid do in cosmetics?

Urocanic Acid functions as: UV absorber / UV filter, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 104-98-3.

What is the Margin of Safety for Urocanic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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