Excellent Cosmetic Ingredient NOAEL Data

Xylose

INCI: XYLOSE (D-XYLOSE)

CAS Number
58-86-6
Function
Skin conditioning agent, humectant, flavoring agent
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS for food use; no cosmetic restrictions; well-established safety profile

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Xylose. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 15000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL >5 other oral rat oral REACH

Expert Verdict

None significant; clean ingredient with long safety history

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Concern Level: None

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Xylose safe in cosmetics?

None significant; clean ingredient with long safety history The EU classifies Xylose as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Xylose allowed in the EU?

Xylose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Xylose do in cosmetics?

Xylose functions as: Skin conditioning agent, humectant, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 58-86-6.

What is the Margin of Safety for Xylose?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Xylose?

The NOAEL (No Observed Adverse Effect Level) for Xylose is 15000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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