Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE

CAS Number

3033-77-0

Function

Not Reported

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status Restricted

EU Max Conc. II/1473

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

3 study endpoints found for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	3.16 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	3.16 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	3.16 mg/kg bw/day	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

excl mark;warn; corr; cancer;health haz

Hazard Statements

Harmful if swallowed or in contact with skin Causes serious eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Suspected of damaging fertility or the unborn child May cause damage to kidneys through prolonged or repeated exposure if swallowed Harmful to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is severely irritating to the eyes and respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Routes of Exposure

The substance can be absorbed into the body in hazardous amounts through the skin, by inhalation of its aerosol and by ingestion.

Expert Verdict

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1473.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE safe in cosmetics?

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1473. The EU classifies 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE as "Restricted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE allowed in the EU?

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE EU regulatory status: Restricted. Maximum allowed concentration: II/1473. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE do in cosmetics?

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 3033-77-0.

What is the NOAEL for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE?

The NOAEL (No Observed Adverse Effect Level) for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE is 3.16 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE classified as hazardous under GHS?

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed or in contact with skin Causes serious eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Suspected of damaging fertility or the unborn child May cause damage to kidneys through prolonged or repeated exposure if swallowed Harmful to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

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