Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE safe in cosmetics?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE has a safety rating of "MODERATE" in our database. EU status: restricted.
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE
Also known as: Oxiranemethanaminium, N,N,N-trimethyl-, chloride0, EINECS 221-221-0, beta,gamma-Epoxypropyltrimethylammonium chloride, (2,3-Epoxypropyl)trimethylammonium chloride, Glycidyl-trimethyl-ammonium chloride (+9 more)
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE (CAS 3033-77-0) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 1.0533333333333335 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/1473; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3033-77-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE is classified GHS Danger (H302, H312, H317, H318, H341, H350, H361, H373) in the chemicals database but is restricted in EU cosmetics at max II/1473.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
trimethyl(oxiran-2-ylmethyl)azanium chloride
InChIKey
PUVAFTRIIUSGLK-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/1473
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
Excl markWarnCorrCancerHealth haz
Hazard Statements
Harmful if swallowed or in contact with skin Causes serious eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Suspected of damaging fertility or the unborn child May cause damage to kidneys through prolonged or repeated exposure if swallowed Harmful to aquatic life with long lasting effects
Short-term Exposure Effects
The substance is severely irritating to the eyes and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body in hazardous amounts through the skin, by inhalation of its aerosol and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / IrritantCorrosive
Hazard Class and Category
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 3
Hazard Statements
- H350 May cause cancer
- H341 Suspected of causing genetic defects
- H361f ***
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H373 **
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1473
(EU) 2019/831
CMR: Carcinogenic Cat. 1B(),Mutagenic Cat. 2(),Reprotoxic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1473
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1668
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (3)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Oxiranemethanaminium, N,N,N-trimethyl-, chloride0
EINECS 221-221-0
beta,gamma-Epoxypropyltrimethylammonium chloride
(2,3-Epoxypropyl)trimethylammonium chloride
Glycidyl-trimethyl-ammonium chloride
N-Glycidyl-N,N,N-trimethylammonium chloride
Glytac A 100
NSC 51213
1-(Trimethylammonio)-2,3-epoxypropane chloride
Trimethylglycidylammonium chloride
N,N,N-Trimethyloxiranemethanaminium chloride
UNII-283XH39M8X
N,N,N-Trimethyl(oxiran-2-yl)methanaminium chloride
Oxiranemethanaminium, N,N,N-trimethyl-, chloride
Chemical Function
No specific technical function
Regulatory Lists
banned; Europe; Personal care
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187272
Frequently Asked Questions
Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE allowed in the EU?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE EU regulatory status: restricted. Maximum allowed concentration: II/1473. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE do in cosmetics?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 3033-77-0.
Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE classified as hazardous under GHS?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed or in contact with skin Causes serious eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Suspected of damaging fertility or the unborn child May cause damage to kidneys through prolonged or repeated exposure if swallowed Harmful to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE used outside cosmetics?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE have different safety status in cosmetics vs industrial chemicals?
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE is classified GHS Danger (H302, H312, H317, H318, H341, H350, H361, H373) in the chemicals database but is restricted in EU cosmetics at max II/1473.
Compliance Tools
Check 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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