Is 2,4-Diaminophenol safe in cosmetics?
2,4-Diaminophenol has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. This ingredient has been reviewed by cir.
2,4-Diaminophenol
Also known as: BRN 0508475, Diaminopropane, EINECS 202-459-4, NSC 5727, UNII-H691WBT7OS
INCI: 2,4-DIAMINOPHENOL
2,4-Diaminophenol (CAS 95-86-3) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye coupler. EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 95-86-3 →
Auto-generated CPSR Part A draft with source citations
Function
Oxidative hair dye coupler
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2,4-diaminophenol
InChIKey
XIWMTQIUUWJNRP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR: Safe for use in hair dyes at ≤0.2% as free base; coal tar hair dye exemption applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,4-Diaminophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
York
0 1994
Verdict: unknown
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 0.2 | Oxidative hair dye products |
| BR | banned | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 2,4-Diaminophenol.
Known Synonyms
BRN 0508475
Diaminopropane
EINECS 202-459-4
NSC 5727
UNII-H691WBT7OS
Chemical Function
Dye
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
2,4-DIAMINOPHENOL
ChEMBL ID
CHEMBL2924225
Frequently Asked Questions
Is 2,4-Diaminophenol allowed in the EU?
2,4-Diaminophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,4-Diaminophenol do in cosmetics?
2,4-Diaminophenol functions as: Oxidative hair dye coupler. It is classified as a cosmetic ingredient in our database. CAS number: 95-86-3.
Is 2,4-Diaminophenol used outside cosmetics?
2,4-Diaminophenol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2,4-Diaminophenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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