2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One
INCI: 2-ETHYL-4-HYDROXY-5-METHYLFURAN-3(2H)-ONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1.52 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 1.52 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
RIFM assessment identifies this as a sensitizer via read-across; use levels must comply with IFRA Standards/QRA limits
Regulatory Flags
Frequently Asked Questions
Is 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One safe in cosmetics?
RIFM assessment identifies this as a sensitizer via read-across; use levels must comply with IFRA Standards/QRA limits The EU classifies 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One allowed in the EU?
2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One do in cosmetics?
2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One functions as: Perfuming (caramel/sweet notes; also known as Homofuronol isomer). It is classified as a cosmetic ingredient in our database. CAS number: 27538-10-9.
What is the Margin of Safety for 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethyl-4-Hydroxy-5-Methylfuran-3(2H)-One is 1.52 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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