5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One

INCI: 5-ETHYL-4-HYDROXY-2-METHYLFURAN-3(2H)-ONE

CAS Number
27538-09-6
Function
Fragrance (sweet, caramellic; occurs naturally in coffee, wine, cheese, melon)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction; FEMA GRAS; RIFM Expert Panel concluded safe (Sept 2021)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Moderate sensitizer requiring IFRA concentration controls (max 0.045% in lip products, 0.27% in face/body leave-on); genotoxicity negative in vivo and not PBT overall per EFSA/RIFM assessment.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One safe in cosmetics?

Moderate sensitizer requiring IFRA concentration controls (max 0.045% in lip products, 0.27% in face/body leave-on); genotoxicity negative in vivo and not PBT overall per EFSA/RIFM assessment. The EU classifies 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One as "permitted". Safety rating: GOOD.

Is 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One allowed in the EU?

5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One do in cosmetics?

5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One functions as: Fragrance (sweet, caramellic; occurs naturally in coffee, wine, cheese, melon). It is classified as a cosmetic ingredient in our database. CAS number: 27538-09-6.

What is the Margin of Safety for 5-Ethyl-4-Hydroxy-2-Methylfuran-3(2H)-One?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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