Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2-Methylpropanal

INCI: 2-METHYLPROPANAL

CAS Number
78-84-2
Function
Fragrance; Nail Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA; FEMA GRAS

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for 2-Methylpropanal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >1450 mg/kg bw/day oral rat oral REACH
NOEL 316 mg/kg bw/day oral rat oral REACH
NOAEL >=7.5 2100 1995 rat inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; excl mark;warn; cancer;health haz
Hazard Statements
Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes. The substance at very high concentrations is irritating to the upper respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated. The substance may cause effects on nervous system. Exposure could cause lowering of consciousness.
Long-term Exposure Effects
Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

Reactive aldehyde with potential skin sensitization via protein binding; eye and respiratory irritant. Volatile — inhalation exposure relevant in spray products. Adhere to IFRA recommended maximum use levels.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 2-Methylpropanal safe in cosmetics?

Reactive aldehyde with potential skin sensitization via protein binding; eye and respiratory irritant. Volatile — inhalation exposure relevant in spray products. Adhere to IFRA recommended maximum use levels. The EU classifies 2-Methylpropanal as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is 2-Methylpropanal allowed in the EU?

2-Methylpropanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methylpropanal do in cosmetics?

2-Methylpropanal functions as: Fragrance; Nail Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 78-84-2.

What is the Margin of Safety for 2-Methylpropanal?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Methylpropanal?

The NOAEL (No Observed Adverse Effect Level) for 2-Methylpropanal is >1450 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Is 2-Methylpropanal classified as hazardous under GHS?

2-Methylpropanal carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 2-Methylpropanal compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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