4-Hydroxyindole

INCI: 4-HYDROXYINDOLE

CAS Number
2380-94-1
Function
Hair dyeing
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically banned by FDA; however, lacks safety substantiation for hair dye use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU-prohibited in hair dye products due to failure to submit required safety data by regulatory deadline. US status restricted due to lack of safety substantiation.

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Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Hydroxyindole safe in cosmetics?

EU-prohibited in hair dye products due to failure to submit required safety data by regulatory deadline. US status restricted due to lack of safety substantiation. The EU classifies 4-Hydroxyindole as "prohibited". Safety rating: POOR.

Is 4-Hydroxyindole allowed in the EU?

4-Hydroxyindole EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Hydroxyindole do in cosmetics?

4-Hydroxyindole functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 2380-94-1.

What is the Margin of Safety for 4-Hydroxyindole?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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