Poor Cosmetic Ingredient

4-Methoxytoluene-2,5-Diamine HCl

INCI: 4-METHOXYTOLUENE-2,5-DIAMINE HCL

CAS Number
56496-88-9
Function
Hair dyeing
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not specifically banned by FDA; covered under coal-tar hair dye exemption, but lacks EU-equivalent safety substantiation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU-banned phenylenediamine derivative associated with severe allergic contact dermatitis, cross-reactivity with other PPD-type dyes, and potential genotoxicity concerns; listed among prohibited substances in hair dye products.

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Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Methoxytoluene-2,5-Diamine HCl safe in cosmetics?

EU-banned phenylenediamine derivative associated with severe allergic contact dermatitis, cross-reactivity with other PPD-type dyes, and potential genotoxicity concerns; listed among prohibited substances in hair dye products. The EU classifies 4-Methoxytoluene-2,5-Diamine HCl as "prohibited". Safety rating: POOR.

Is 4-Methoxytoluene-2,5-Diamine HCl allowed in the EU?

4-Methoxytoluene-2,5-Diamine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Methoxytoluene-2,5-Diamine HCl do in cosmetics?

4-Methoxytoluene-2,5-Diamine HCl functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 56496-88-9.

What is the Margin of Safety for 4-Methoxytoluene-2,5-Diamine HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 4-Methoxytoluene-2,5-Diamine HCl compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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