Is 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE safe in cosmetics?
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE has a safety rating of "MODERATE" in our database. EU status: restricted. 3 toxicological study endpoint(s) are available in our database.
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE
Also known as: Benzenepropanal, 4-(1,1-dimethylethyl)-, Bourgeonal, BRN 2439407, p-tert-Butyldihydrocinnamaldehyde, p-tert-Butylhydrocinnamic aldehyde (+3 more)
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE (CAS 18127-01-0) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max III/155. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 18127-01-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE is classified GHS Danger (H301, H315, H317, H361, H373, H411, H412) in the chemicals database but is restricted in EU cosmetics at max III/155.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/155
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =25 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
17.65%
DPRA Lys %
0.97%
KeratinoSens IC50
67.727 µM
hCLAT CV75
46.4 µg/mL
LLNA EC3
9.5%
NESIL
4050 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Report to RIFM by Givaudan (RIFM DB#41055); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database; HPPT: [357] Epstein WL (1980): Report to RIFM, 25 June, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 4050 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Max: 0.006.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.006
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE.
Regulatory Flags
cosing-sourced
eu-restricted
fragrance
needs-enrichment
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE by CAS number or substance name.
Studies
3
Lowest NOAEL
5 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Benzenepropanal, 4-(1,1-dimethylethyl)-
Bourgeonal
BRN 2439407
p-tert-Butyldihydrocinnamaldehyde
p-tert-Butylhydrocinnamic aldehyde
4-(1,1-Dimethylethyl)benzenepropanal
EINECS 242-016-2
UNII-H3XVS6E70V
Chemical Function
Fragrance
Regulatory Lists
consumer_product
Europe; Personal care; restricted
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183621
Frequently Asked Questions
Is 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE allowed in the EU?
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE EU regulatory status: restricted. Maximum allowed concentration: III/155. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE do in cosmetics?
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 18127-01-0.
What is the NOAEL for 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE?
The NOAEL (No Observed Adverse Effect Level) for 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE is =5 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE used outside cosmetics?
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE have different safety status in cosmetics vs industrial chemicals?
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE is classified GHS Danger (H301, H315, H317, H361, H373, H411, H412) in the chemicals database but is restricted in EU cosmetics at max III/155.
Compliance Tools
Check 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal)
Moderate
Chemical family
Fragrance (lily-of-the-valley note)
4-T-Butyl Benzaldehyde
Moderate
Browse nearby
Fragrance ingredient
4-T-Butyl Styrene
Poor
Browse nearby
Masking / fragrance (limited cosmetic...
Is 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4-TERT-BUTYLDIHYDROCINNAMALDEHYDE in your formulation.