Good Active Ingredient NOAEL Data GHS Classified

Acetic Acid — Deep Research Profile

INCI: ACETIC ACID

CAS Number
64-19-7
Function
fragrance component, general SCCS fragrance guidelines and allergen labelling thresholds apply
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Safety Assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Acetic Acid — Deep Research Profile. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 390 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 4500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 4500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 400 mg/kg bw/day oral rabbit Chronic COSMOS_DB
NOAEL 700 mg/kg bw/day oral rabbit Chronic COSMOS_DB
NOAEL 1600 mg/kg bw/day oral rabbit Developmental COSMOS_DB
dose_tested 400 mg/kg bw/day oral rabbit Chronic COSMOS_DB
dose_tested 700 mg/kg bw/day oral rabbit Chronic COSMOS_DB
dose_tested 1600 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 290 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; corr; excl mark;warn; cancer;health haz
Hazard Statements
Flammable liquid and vapour Harmful in contact with skin or if inhaled May be harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Causes damage to the respiratory tract through prolonged or repeated exposure if inhaled Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Lungs may be affected by repeated or prolongated exposure to an aerosol of this substance. Risk of tooth erosion upon repeated or prolongated exposure to an aerosol of this substance.
Routes of Exposure
Serious local effects by all routes of exposure.

Expert Verdict

Acetic Acid is generally considered safe for use as a fragrance component in cosmetics, subject to SCCS fragrance guidelines and allergen labelling thresholds.

⚠️
Concern Level: Low

Regulatory Flags

epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Acetic Acid — Deep Research Profile safe in cosmetics?

Acetic Acid is generally considered safe for use as a fragrance component in cosmetics, subject to SCCS fragrance guidelines and allergen labelling thresholds. The EU classifies Acetic Acid — Deep Research Profile as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Acetic Acid — Deep Research Profile allowed in the EU?

Acetic Acid — Deep Research Profile EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acetic Acid — Deep Research Profile do in cosmetics?

Acetic Acid — Deep Research Profile functions as: fragrance component, general SCCS fragrance guidelines and allergen labelling thresholds apply. It is classified as a Active Ingredient in our database. CAS number: 64-19-7.

What is the Margin of Safety for Acetic Acid — Deep Research Profile?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acetic Acid — Deep Research Profile?

The NOAEL (No Observed Adverse Effect Level) for Acetic Acid — Deep Research Profile is 390 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is Acetic Acid — Deep Research Profile classified as hazardous under GHS?

Acetic Acid — Deep Research Profile carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Harmful in contact with skin or if inhaled May be harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Causes damage to the respiratory tract through prolonged or repeated exposure if inhaled Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Acetic Acid — Deep Research Profile compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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