Excellent Active Ingredient

Alpha-Glucan Oligosaccharide

INCI: ALPHA-GLUCAN OLIGOSACCHARIDE

CAS Number
27707-45-5
Function
prebiotic, skin-conditioning
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as cosmetic ingredient; safest microbiome category from FDA perspective with no live organism viability concerns; MoCRA 2026 compliance required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Gold-standard prebiotic substrate for microbiome-targeting formulations that selectively feeds beneficial bacteria while inhibiting harmful species and eliminating biofilms through competitive exclusion of pathogens. Quorum-sensing inhibition provides meaningful anti-acne mechanism. Most regulatory-friendly microbiome ingredient category with no live organisms, no TVC complications, or prohibited ingredient conflicts. Performs best in synbiotic combinations with inulin and lactobacillus ferments; concentration precision is critical for maintaining microbiome selectivity.

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Concern Level: None

Regulatory Flags

prebiotic no-live-organisms competitive-exclusion synbiotic-combination-optimized quorum-sensing-inhibition antibiofilm microbiome-selectivity-critical microbiome-friendly selective-carbon-source

Frequently Asked Questions

Is Alpha-Glucan Oligosaccharide safe in cosmetics?

Gold-standard prebiotic substrate for microbiome-targeting formulations that selectively feeds beneficial bacteria while inhibiting harmful species and eliminating biofilms through competitive exclusion of pathogens. Quorum-sensing inhibition provides meaningful anti-acne mechanism. Most regulatory-friendly microbiome ingredient category with no live organisms, no TVC complications, or prohibited ingredient conflicts. Performs best in synbiotic combinations with inulin and lactobacillus ferments; concentration precision is critical for maintaining microbiome selectivity. The EU classifies Alpha-Glucan Oligosaccharide as "permitted". Safety rating: EXCELLENT.

Is Alpha-Glucan Oligosaccharide allowed in the EU?

Alpha-Glucan Oligosaccharide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alpha-Glucan Oligosaccharide do in cosmetics?

Alpha-Glucan Oligosaccharide functions as: prebiotic, skin-conditioning. It is classified as a Active Ingredient in our database. CAS number: 27707-45-5.

What is the Margin of Safety for Alpha-Glucan Oligosaccharide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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