Is Alpha-Glucan Oligosaccharide safe in cosmetics?
Alpha-Glucan Oligosaccharide has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Alpha-Glucan Oligosaccharide
INCI: ALPHA-GLUCAN OLIGOSACCHARIDE
Alpha-Glucan Oligosaccharide (CAS 27707-45-5) is a cosmetic active ingredient functioning as prebiotic, skin-conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 27707-45-5 →
Auto-generated CPSR Part A draft with source citations
Function
prebiotic, skin-conditioning
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as cosmetic ingredient; safest microbiome category from FDA perspective with no live organism viability concerns; MoCRA 2026 compliance required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Alpha-Glucan Oligosaccharide.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
9 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair, prebiotic", "mechanism_of_action": "Microbiome modulation, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Microbiome…
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "75", "estimated_cost_per_kg_usd_high": "140", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "France", "bulk_discount_threshold_kg": "25", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Inulin, Prebio…
deodorant
{"cas_number": "22328-35-0", "ingredient_class": "prebiotic_deodorant", "mechanism_of_action": "microbiome_modulation", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "12-24", "odor_reduction_pct": "45-65", "bacteriostatic": "no", "bactericidal": "no", "target_bacteria": "promotes beneficial flora", "microbiome_impact": "prebiotic", "axillary_microbiome_effect": "s…
humectant
{"cas_number": "68424-04-4", "ingredient_class": "humectant/polysaccharide/prebiotic", "molecular_weight_Da": "variable", "chemical_type": "polysaccharide", "water_binding_mechanism": "hydrogen_bonding/hygroscopic", "water_holding_capacity_g_per_g": "0.5-0.8", "hygroscopicity_at_50_RH": "good", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_redu…
microbiome
{"ingredient_class": "prebiotic", "live_organism_content": "no", "bioactive_components": "oligosaccharides", "molecular_weight_range_Da": "500-2000", "pH_of_ingredient": "5.0-7.0", "mechanism_of_action": "competitive_exclusion/barrier_strengthening", "skin_microbiome_effect": "S_epidermidis_promoting", "scalp_microbiome_effect": "balancing", "anti_aging_mechanism": "barrier_repair", "skin_barrier_…
microbiome_impact
{"microbiome_effect": "positive", "prebiotic": "yes", "probiotic_compatible": "yes", "preservative_effect_on_microbiome": "Prebiotic; enhances S. epidermidis growth; inhibits S. aureus colonization", "gut_microbiome_risk": "low", "microbiome_recovery_time": "<2 days", "selective_antimicrobial": "no", "beneficial_bacteria_support": "S. epidermidis, beneficial skin bacteria", "pathogen_inhibition": …
self_tanning
{"cas_number": "68424-04-4", "ingredient_class": "tan_extender", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_conc…
sensory
{"silky": "liquid", "smooth, glides easily": "smooth, prebiotic", "dry-touch, non-greasy": "balanced, protected", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "no", "1.40": "1.40", "transparent": "transparent", "colorless": "colorless", "excellent": "good", "light": "light", "synthetic": "biotechnology"}
Expert Verdict
Expert safety assessment and concern-level summary for Alpha-Glucan Oligosaccharide.
Regulatory Flags
prebiotic
no-live-organisms
competitive-exclusion
synbiotic-combination-optimized
quorum-sensing-inhibition
antibiofilm
microbiome-selectivity-critical
microbiome-friendly
selective-carbon-source
Frequently Asked Questions
Is Alpha-Glucan Oligosaccharide allowed in the EU?
Alpha-Glucan Oligosaccharide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alpha-Glucan Oligosaccharide do in cosmetics?
Alpha-Glucan Oligosaccharide functions as: prebiotic, skin-conditioning. It is classified as a Active Ingredient in our database. CAS number: 27707-45-5.
Compliance Tools
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Substance Compliance
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MoS Calculator
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