Is Acetyl Tetrapeptide-5 safe in cosmetics?
Acetyl Tetrapeptide-5 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Acetyl Tetrapeptide-5
INCI: ACETYL TETRAPEPTIDE-5
Acetyl Tetrapeptide-5 (CAS Insufficient Data) is a cosmetic active ingredient functioning as Anti-edema peptide for periorbital area. Mechanism: ACE inhibition —. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Insufficient Data →
Auto-generated CPSR Part A draft with source citations
Function
Anti-edema peptide for periorbital area. Mechanism: ACE inhibition — dose-dependent inhibition of angiotensin-converting enzyme reduces microvascular pressure; reduced vascular permeability — decreases endothelial cell permeability, inhibiting interstitial fluid leakage; anti-glycation — protects collagen and SOD from fructose-mediated glycation, preserving elasticity. Strengthens capillary walls, reduces dark circle appearance.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. No pre-market approval required under MoCRA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tetrapeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "820959-17-9", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_aging
{"anti_aging_claim": "firming, anti-puffiness", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept …
anti_pollution
{"cas_number": "820959-17-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.01", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.1", "product_type": "Eye Cream", "function_at_concentration": "Anti-puffiness, drainage", "source": "Supplier TDS (Eyeseryl)"}
peptide
{"cas_number": "820959-17-9", "trade_name": "Eyeseryl", "peptide_sequence_amino_acids": "Ac-Gly-Gln-Pro-Arg", "peptide_length_residues": "4", "molecular_weight_daltons": "539.6", "peptide_class": "signal", "mechanism_of_action": "Anti-edema, improves lymphatic drainage, reduces periorbital puffiness", "target_protein_or_receptor": "Aquaporin modulation", "collagen_boost_pct_in_vitro": "18", "elast…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Anti-puffiness peptide", "formulation_note": "Standard peptide stability", "source": "Formulation literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "anti-puffiness", "skin_benefit_secondary": "draina…
synergy
{"inci_name_2": "Caffeine", "synergy_type": "efficacy-boost", "synergy_description": "De-puffing peptide with vasoconstrictor for eye area", "combined_benefit": "Superior under-eye bag reduction, enhanced microcirculation, reduced puffiness", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Tetrapeptide-5 reduces edema; caffeine constricts blood vessels and mobilizes fat", "optimal_ratio": "…
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tetrapeptide-5.
Frequently Asked Questions
Is Acetyl Tetrapeptide-5 allowed in the EU?
Acetyl Tetrapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tetrapeptide-5 do in cosmetics?
Acetyl Tetrapeptide-5 functions as: Anti-edema peptide for periorbital area. Mechanism: ACE inhibition — dose-dependent inhibition of angiotensin-converting enzyme reduces microvascular pressure; reduced vascular permeability — decreases endothelial cell permeability, inhibiting interstitial fluid leakage; anti-glycation — protects collagen and SOD from fructose-mediated glycation, preserving elasticity. Strengthens capillary walls, reduces dark circle appearance.. It is classified as a Active Ingredient in our database. CAS number: Insufficient Data.
Compliance Tools
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MoS Calculator
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ACETALDEHYDE
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Fragrance
ACETOBACTER FERMENT EXTRACT FILTRATE
Good
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ACETOBACTER/ASPERGILLUS/LACTOBACILLUS/LEUCONOSTOC/PEDIOCOCCUS/SACCHAROMYCES/ZYGOSACCHAROMYCES/CITRUS UNSHIU FRUIT/CITRUS JAPONICA FRUIT/CITRUS JUNOS FRUIT/ APPLE FRUIT/BANANA FRUIT/PAPAYA FRUIT/ PYRUS SEROTINA FRUIT/ DIOSPYROS KAKI FRUIT/WATERMELON FRUIT/PEACH FRUIT/ PRUNUS MUME FRUIT/FIG FRUIT/CHAENOMELES SINENSIS FRUIT/ERIOBOTRYA JAPONICA FRUIT/APRICOT FRUIT/ ZIZYPHUS JUJUBA FRUIT/CUCURBITA MAXIMA FRUIT/CASTANEA CRENATA FRUIT/VITIS COIGNETIAE FRUIT/RASPBERRY FRUIT/MOMORDICA GROSVENORII FRUIT/LYCIUM CHINENSE FRUIT/GLYCINE MAX SEED/PHASEOLUS ANGULARIS SEED/CANAVALIA ENSIFORMIS SEED/RICE SEED/HORDEUM VULGARE SEED/COIX LACRYMA-JOBI MA-YUEN SEED/ECHINOCHLOA CRUS-GALLI SEED/SETARIA ITALICA SEED/MILLET SEED/HEMEROCALLIS FULVA FLOWER/CABBAGE LEAF/STEM/MORUS BOMBYCIS LEAF/PERILLA FRUTESCENS LEAF/IPOMOEA BATATAS ROOT/COLOCASIA ANTIQUORUM TUBER/DIOSCOREA BATATAS RHIZOME/IRIDEA LAMINARIOIDES/LAMINARIA JAPONICA/NEMACYSTUS DECIPIENS/UNDARIA PINNATIFIDA/RADISH ROOT/TURNIP ROOT/CARROT ROOT/ARCTIUM LAPPA ROOT/NELUMBO NUCIFERA RHIZOME/ONION BULB/LILIUM AURATUM BULB/LICORICE ROOT/SAGITTARIA TRIFOLIA ROOT/SESAME SEED/GINKGO BILOBA SEED/JUGLANS SUBCORDIFORMIS FRUIT/PANAX GINSENG SEED/ACTINIDIA POLYGAMA FRUIT/HYDNUM ERINACEUM FRUITING BODY/GRIFOLA FRONDOSA FRUITING BODY/PRUNUS SALICINA FRUIT/AKEBIA QUINATA FRUIT/CRATAEGUS CUNEATA FRUIT/CORNUS OFFICINALIS FRUIT/NEPHELIUM LONGANA FRUIT/HOUTTUYNIA CORDATA/ARTEMISIA PRINCEPS/SASA VEITCHII LEAF/GLECHOMA HEDERACEA/CHAMOMILLA RECUTITA FLOWER/EQUISETUM ARVENSE/CASSIA OBTUSIFOLIA SEED/TARAXACUM OFFICINALE/ISODON JAPONICUS/SAFFLOWER FLOWER/PLANTAGO ASIATICA/SMALLANTHUS SONCHIFOLIUS ROOT/GARLIC BULB/GINGER RHIZOME/BEET RHIZOME/POLYGONUM ODORATUM RHIZOME/TURMERIC RHIZOME/ACANTHOPANAX SIEBOLDIANUS ROOT/PINUS KORAIENSIS SEED/LENTINUS EDODES FRUITING BODY/AURICULARIA AURICULA/VITIS LABRUSCA FRUIT/HELIANTHUS TUBEROSUS TUBER FERMENT EXTRACT
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