Moderate Cosmetic Ingredient NOAEL Data

Allyl Caproate

INCI: ALLYL CAPROATE (SYN. ALLYL HEXANOATE)

CAS Number
123-68-2
Function
Fragrance, Astringent, Skin Conditioning - Emollient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; FEMA GRAS (No. 2032) for flavoring

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for Allyl Caproate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 12 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 65 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 125 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 250 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 15 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 65 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 100 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 125 mg/kg bw/day oral rat Chronic COSMOS_DB

Expert Verdict

Toxic if swallowed, in contact with skin, or if inhaled at concentrate level; IFRA standard limits apply; must control free allyl alcohol content

⚠️
Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Allyl Caproate safe in cosmetics?

Toxic if swallowed, in contact with skin, or if inhaled at concentrate level; IFRA standard limits apply; must control free allyl alcohol content The EU classifies Allyl Caproate as "restricted". Safety rating: MODERATE. 9 toxicological study endpoint(s) are available in our database.

Is Allyl Caproate allowed in the EU?

Allyl Caproate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Allyl Caproate do in cosmetics?

Allyl Caproate functions as: Fragrance, Astringent, Skin Conditioning - Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 123-68-2.

What is the Margin of Safety for Allyl Caproate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Allyl Caproate?

The NOAEL (No Observed Adverse Effect Level) for Allyl Caproate is 12 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Allyl Caproate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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