Is Aminoguanidine HCl safe in cosmetics?
Aminoguanidine HCl has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Aminoguanidine HCl
Also known as: Hydrazinecarboximidamide, monohydrochloride, Pimagedine hydrochloride, Carbazamidine monohydrochloride, Guanidine, amino-, hydrochloride, Hydrazinecarboximidamide, hydrochloride (1:1) (+5 more)
INCI: AMINOGUANIDINE HCL
Aminoguanidine HCl (CAS 1937-19-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1937-19-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aminoguanidine HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H360).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin Conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-aminoguanidine;hydrochloride
InChIKey
UBDZFAGVPPMTIT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically prohibited by FDA; not widely used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminoguanidine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Aminoguanidine HCl.
Known Synonyms
Hydrazinecarboximidamide, monohydrochloride
Pimagedine hydrochloride
Carbazamidine monohydrochloride
Guanidine, amino-, hydrochloride
Hydrazinecarboximidamide, hydrochloride (1:1)
EINECS 217-707-7
Guanylhydrazine hydrochloride
Hydrazinecarboximidamide hydrochloride
Pimagedine HCl
UNII-A2Z7G2RGAH
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIMAGEDINE HYDROCHLORIDE
ChEMBL ID
CHEMBL1256292
Max Phase
-1
Frequently Asked Questions
Is Aminoguanidine HCl allowed in the EU?
Aminoguanidine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminoguanidine HCl do in cosmetics?
Aminoguanidine HCl functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 1937-19-5.
Is Aminoguanidine HCl used outside cosmetics?
Aminoguanidine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aminoguanidine HCl have different safety status in cosmetics vs industrial chemicals?
Aminoguanidine HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H360).
Compliance Tools
Check Aminoguanidine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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