Is Aminolevulinic Acid HCl safe in cosmetics?
Aminolevulinic Acid HCl has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Aminolevulinic Acid HCl
Also known as: 5-Aminolevulinate hydrochloride, 5-Aminolevulinic acid hydrochloride, EINECS 226-679-5, NSC 18509, Levulan Kerastick (+3 more)
INCI: AMINOLEVULINIC ACID HCL
Aminolevulinic Acid HCl (CAS 5451-09-2) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Hair Conditioning, Skin Conditioning. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 5451-09-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, Hair Conditioning, Skin Conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
5-amino-4-oxopentanoic acid;hydrochloride
InChIKey
ZLHFONARZHCSET-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
FDA-approved as a prescription drug (Levulan Kerastick) for photodynamic therapy; cosmetic use would likely trigger drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminolevulinic Acid HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Aminolevulinic Acid HCl.
Known Synonyms
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid hydrochloride
EINECS 226-679-5
NSC 18509
Levulan Kerastick
UNII-V35KBM8JGR
5-aminolevulinic acid.HCl
delta-Aminolevulinic acid hydrochloride
Chemical Function
Biocide
Softener and conditioner
Regulatory Lists
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMINOLEVULINIC ACID HYDROCHLORIDE
ChEMBL ID
CHEMBL1200582
Max Phase
4
Adverse Event Associations
17
Frequently Asked Questions
Is Aminolevulinic Acid HCl allowed in the EU?
Aminolevulinic Acid HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminolevulinic Acid HCl do in cosmetics?
Aminolevulinic Acid HCl functions as: Antimicrobial, Hair Conditioning, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5451-09-2.
Is Aminolevulinic Acid HCl used outside cosmetics?
Aminolevulinic Acid HCl also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Chemical family
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