Is Amylcinnamyl Alcohol safe in cosmetics?
Amylcinnamyl Alcohol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Amylcinnamyl Alcohol
Also known as: 3-06-00-02542, alpha-Amylcinnamic alcohol, 2-Amyl-3-phenyl-2-propen-1-ol, 2-Benzylideneheptanol, 2-Benzylidene-1-heptanol (+7 more)
INCI: AMYLCINNAMYL ALCOHOL
Amylcinnamyl Alcohol (CAS 101-85-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 101-85-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not restricted by FDA (no allergen labeling requirement in US); IFRA use limits apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amylcinnamyl Alcohol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Amylcinnamyl Alcohol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.3%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
— max 0.1% in finished products
Source: ESSCA/IVDK
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
5%
DPRA Lys %
0%
KeratinoSens IC50
44.1 µM
hCLAT CV75
46.1 µg/mL
LLNA EC3
25%
NESIL
3543 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Human: positive
Source: LLNA: Kern et al. (2010); DPRA: Hoffmann et al., 2018; KS: No reference provided in NICEATM database; hCLAT: No reference provided in NICEATM database; HPPT: [39] Kligman AM (1973): Report to RIFM, 13 June, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 105 | 0 | 3543 | 3543 | non-sensitizer |
| HMT | - | 0 | 5184 | - | - |
| HRIPT | - | 0 | 3543.31 | - | - |
| HRIPT | - | 0 | 5039.37 | - | - |
| HMT | - | 0 | 5184 | - | - |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
India: Restricted
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "fragrance-mix-II", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "ifra_max_level_pct": "0.1", "source": "ESSCA/IVDK"}
regulatory
{"eu_status": "restricted", "us_status": "allowed", "eu_max_concentration": "0.001", "restricted_in": "rinse-off: >0.01%, leave-on: >0.001%", "regulation_reference": "Annex III/205"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (5)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Amylcinnamyl Alcohol.
Regulatory Flags
potential-allergen
fragrance-component
eu_children_restricted
ifra_fragrance
fda_food_additive
eu_cosing_listed
Known Synonyms
3-06-00-02542
alpha-Amylcinnamic alcohol
2-Amyl-3-phenyl-2-propen-1-ol
2-Benzylideneheptanol
2-Benzylidene-1-heptanol
BRN 3127316
Buxinol
EINECS 202-982-8
FEMA No. 2065
alpha-Pentylcinnamyl alcohol
2-(Phenylmethylene)-1-heptanol
UNII-DKB52S61GU
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Cleaning products and household care - air freshener; detected; Europe
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
children; Europe; Personal care
children; Europe; nondetect; Personal care
consumer_product; Europe; nondetect
consumer_product; detected; Europe
Europe; Personal care; restricted
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Amylcinnamyl Alcohol allowed in the EU?
Amylcinnamyl Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Amylcinnamyl Alcohol do in cosmetics?
Amylcinnamyl Alcohol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 101-85-9.
Compliance Tools
Check Amylcinnamyl Alcohol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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