Is Diphenyl Methane safe in cosmetics?
Diphenyl Methane has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Diphenyl Methane
Also known as: AI3-28021-X, Benzene, benzyl-, EINECS 202-978-6, Toluene, alpha-phenyl-, UNII-K3E387I0BC (+5 more)
INCI: DIPHENYLMETHANE
Diphenyl Methane (CAS 101-81-5) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with green odor profile. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 101-81-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diphenyl Methane is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient with green odor profile
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
benzylbenzene
InChIKey
CZZYITDELCSZES-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted, not restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diphenyl Methane.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Dye
Flavouring and nutrient
Fragrance
Solvent
Surface modifier
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Diphenyl Methane.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
AI3-28021-X
Benzene, benzyl-
EINECS 202-978-6
Toluene, alpha-phenyl-
UNII-K3E387I0BC
(phenylmethyl)benzene
1,1'-dimethylenebis(benzene)
1,1'-methylenebisbenzene
alpha-phenyltoluene
ditan
Chemical Function
Solvent
Deodorizer
Dye
Surface modifier
Flavouring and nutrient
Fragrance
Regulatory Lists
Europe; Other direct contact consumer goods; residue
IFRA Transparency
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIPHENYLMETHANE
ChEMBL ID
CHEMBL1796022
Frequently Asked Questions
Is Diphenyl Methane allowed in the EU?
Diphenyl Methane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diphenyl Methane do in cosmetics?
Diphenyl Methane functions as: Fragrance ingredient with green odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 101-81-5.
Is Diphenyl Methane used outside cosmetics?
Diphenyl Methane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diphenyl Methane have different safety status in cosmetics vs industrial chemicals?
Diphenyl Methane is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).
Compliance Tools
Check Diphenyl Methane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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