Good Fragrance

Anisic Acid

Also known as: Benzoic acid, 4-methoxy-, Dermosoft 688, 4-Acetylanisole, 4-10-00-00346, Anisic acid, p-isomer (+7 more)

INCI: P-ANISIC ACID

Anisic Acid (CAS 100-09-4) is a cosmetic fragrance functioning as Fragrance, Antimicrobial Preservation Booster. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 100-09-4 →

Auto-generated CPSR Part A draft with source citations

CAS Number

100-09-4

View industrial chemical safety profile →

Function

Fragrance, Antimicrobial Preservation Booster

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C8H8O3

152.15 g/mol

EC Number

202-818-5

PubChem CID

7478

IUPAC Name

4-methoxybenzoic acid

InChIKey

ZEYHEAKUIGZSGI-UHFFFAOYSA-N

ChEBI: CHEBI:40813 UNII: 4SB6Y7DMM3 Wikidata: Q4566032

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes No CIR monograph. No SCCS opinion. RIFM 2019 is sole comprehensive safety assessment.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Anisic Acid.

Calculate MoS for your specific formulation with the MoS Calculator.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Anisic Acid across SCCS product categories, with measured dermal absorption where available.

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Cosmetic-Specific Mechanism

Category: UV filter

Receptor targets: ERα (limited)

LOEC: 10 µM

EU status: allowed

weak modulator

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

10 - 100 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Additional Ingredient Properties

3 property records from structured ingredient metadata.

ecotoxicity

{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…

ph_stability

{"optimal_ph_min": "4.0", "optimal_ph_max": "5.5", "stable_ph_min": "3.5", "stable_ph_max": "6.0", "degrades_above_ph": "6.5", "ph_dependent_function": "Active below pH 5.5; organic acid preservative", "formulation_note": "pH determines undissociated acid concentration", "source": "PMC 2023"}

pregnancy_detail

{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; natural preservative", "source": "COSMOS"}

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (1)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

Regulatory (6)

JECFA Number

883