Good Fragrance NOAEL Data

Anisic Acid

INCI: P-ANISIC ACID

CAS Number
100-09-4
Function
Fragrance, Antimicrobial Preservation Booster
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR monograph. No SCCS opinion. RIFM 2019 is sole comprehensive safety assessment.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Anisic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 20 mg/kg bw/day oral rat oral REACH
NOAEL 20 mg/kg bw/day oral - oral REACH

Expert Verdict

Permitted without restriction as fragrance and preservation booster; pH-dependent antimicrobial activity optimized below pH 5.0.

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Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Anisic Acid safe in cosmetics?

Permitted without restriction as fragrance and preservation booster; pH-dependent antimicrobial activity optimized below pH 5.0. The EU classifies Anisic Acid as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Anisic Acid allowed in the EU?

Anisic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Anisic Acid do in cosmetics?

Anisic Acid functions as: Fragrance, Antimicrobial Preservation Booster. It is classified as a Fragrance in our database. CAS number: 100-09-4.

What is the Margin of Safety for Anisic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Anisic Acid?

The NOAEL (No Observed Adverse Effect Level) for Anisic Acid is 20 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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