Regulatory Status
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Safety Data
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Expert Verdict
HIGH CONCERN - A. muricata is listed in the EFSA Compendium of botanicals with naturally occurring substances of possible concern; ~200 bioactive compounds identified including neurotoxic ACGs; bark preparations showed high toxicity on human mesencephalic cells in vitro; epidemiological association with atypical parkinsonism in Caribbean populations; animal studies show tau protein accumulation and nigral neurodegeneration
Regulatory Flags
Frequently Asked Questions
Is Annona Muricata Bark Extract safe in cosmetics?
HIGH CONCERN - A. muricata is listed in the EFSA Compendium of botanicals with naturally occurring substances of possible concern; ~200 bioactive compounds identified including neurotoxic ACGs; bark preparations showed high toxicity on human mesencephalic cells in vitro; epidemiological association with atypical parkinsonism in Caribbean populations; animal studies show tau protein accumulation and nigral neurodegeneration The EU classifies Annona Muricata Bark Extract as "permitted". Safety rating: POOR.
Is Annona Muricata Bark Extract allowed in the EU?
Annona Muricata Bark Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Annona Muricata Bark Extract do in cosmetics?
Annona Muricata Bark Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng.
What is the Margin of Safety for Annona Muricata Bark Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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