Regulatory Status
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Safety Data
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Expert Verdict
HIGH CONCERN - marketed dietary supplements from A. muricata leaves and stems were directly tested and showed high toxicity on human mesencephalic cells (Höllerhage et al., 2015, cited in EFSA assessment); this specific combination was the subject that raised the neurotoxicity alarm
Regulatory Flags
Frequently Asked Questions
Is Annona Muricata Leaf/Stem Extract safe in cosmetics?
HIGH CONCERN - marketed dietary supplements from A. muricata leaves and stems were directly tested and showed high toxicity on human mesencephalic cells (Höllerhage et al., 2015, cited in EFSA assessment); this specific combination was the subject that raised the neurotoxicity alarm The EU classifies Annona Muricata Leaf/Stem Extract as "permitted". Safety rating: POOR.
Is Annona Muricata Leaf/Stem Extract allowed in the EU?
Annona Muricata Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Annona Muricata Leaf/Stem Extract do in cosmetics?
Annona Muricata Leaf/Stem Extract functions as: Skin conditioning (by analogy to leaf extract). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.
What is the Margin of Safety for Annona Muricata Leaf/Stem Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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