Moderate Cosmetic Ingredient NOAEL Data

Benzothiazole

INCI: BENZOTHIAZOLE

CAS Number
95-16-9
Function
Fragrance ingredient (RIFM-assessed); not a UV filter
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically regulated as a cosmetic active; RIFM fragrance ingredient safety assessment published (2018)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Benzothiazole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5.1 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 5.1 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Known rubber accelerator allergen class with environmental persistence concerns. Use restricted to fragrance at low levels with IFRA compliance required.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Benzothiazole safe in cosmetics?

Known rubber accelerator allergen class with environmental persistence concerns. Use restricted to fragrance at low levels with IFRA compliance required. The EU classifies Benzothiazole as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Benzothiazole allowed in the EU?

Benzothiazole EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzothiazole do in cosmetics?

Benzothiazole functions as: Fragrance ingredient (RIFM-assessed); not a UV filter. It is classified as a cosmetic ingredient in our database. CAS number: 95-16-9.

What is the Margin of Safety for Benzothiazole?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Benzothiazole?

The NOAEL (No Observed Adverse Effect Level) for Benzothiazole is 5.1 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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