Bis-Methoxyethoxy Methane

INCI: BIS-METHOXYETHOXY METHANE

CAS Number
4431-83-8 (methylenebis(2-methoxyethyl ether) / formal of 2-methoxyethanol)
Function
Solvent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not individually reviewed by CIR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL: potential metabolic release of 2-methoxyethanol, a known reproductive toxicant (Cat 1B CMR under CLP). Must confirm hydrolysis fate. Glycol ether family โ€” ECHA has flagged multiple members for CMR properties. Requires toxicological dossier before use.

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Concern Level: High

Frequently Asked Questions

Is Bis-Methoxyethoxy Methane safe in cosmetics?

CRITICAL: potential metabolic release of 2-methoxyethanol, a known reproductive toxicant (Cat 1B CMR under CLP). Must confirm hydrolysis fate. Glycol ether family โ€” ECHA has flagged multiple members for CMR properties. Requires toxicological dossier before use. The EU classifies Bis-Methoxyethoxy Methane as "prohibited". Safety rating: POOR.

Is Bis-Methoxyethoxy Methane allowed in the EU?

Bis-Methoxyethoxy Methane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Bis-Methoxyethoxy Methane do in cosmetics?

Bis-Methoxyethoxy Methane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 4431-83-8 (methylenebis(2-methoxyethyl ether) / formal of 2-methoxyethanol).

What is the Margin of Safety for Bis-Methoxyethoxy Methane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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