Excellent Emollient Dermal Penetration

Cetyl Ethylhexanoate

INCI: CETYL ETHYLHEXANOATE

CAS Number
59130-69-7
Function
Lightweight, dry-touch ester emollient functioning as skin-conditioning agent and texture modifier. Superior sensory profile for SPF and color cosmetics. Low comedogenicity. Does not function as a penetration enhancer at standard use levels.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Low comedogenicity rating in rabbit ear assay. Widely used in sunscreen and color cosmetic formulations for its dry-touch, non-greasy sensory profile. Good compatibility with UV filters.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Cetyl Ethylhexanoate, relevant to systemic exposure and MoS calculations.

Absorption %
2-6%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
368.6 Da
Log P
9.8
Systemic Absorption
minimal
Topical Bioavailability
1-4%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: CIR

Expert Verdict

A leading dry-touch ester emollient preferred in SPF and color cosmetic formulations with low comedogenicity and excellent UV-filter compatibility, making it a better-tolerated alternative to isopropyl myristate/palmitate in sun care. No significant safety concerns.

โš ๏ธ
Concern Level: None

Frequently Asked Questions

Is Cetyl Ethylhexanoate safe in cosmetics?

A leading dry-touch ester emollient preferred in SPF and color cosmetic formulations with low comedogenicity and excellent UV-filter compatibility, making it a better-tolerated alternative to isopropyl myristate/palmitate in sun care. No significant safety concerns. The EU classifies Cetyl Ethylhexanoate as "permitted". Safety rating: EXCELLENT.

Is Cetyl Ethylhexanoate allowed in the EU?

Cetyl Ethylhexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cetyl Ethylhexanoate do in cosmetics?

Cetyl Ethylhexanoate functions as: Lightweight, dry-touch ester emollient functioning as skin-conditioning agent and texture modifier. Superior sensory profile for SPF and color cosmetics. Low comedogenicity. Does not function as a penetration enhancer at standard use levels.. It is classified as a Emollient in our database. CAS number: 59130-69-7.

What is the Margin of Safety for Cetyl Ethylhexanoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Cetyl Ethylhexanoate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cetyl Ethylhexanoate in your formulation.