Is Acid Blue 1 safe in cosmetics?
Acid Blue 1 has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Acid Blue 1
Also known as: C.I. Food Blue 3, Patent Blue VF, Patent Blue Violet, C.I. Acid Blue 1, sodium salt, C.I. Acid Blue 1 (+14 more)
INCI: CI 42045
Acid Blue 1 (CAS 129-17-9) is a cosmetic cosmetic ingredient functioning as Colorant. Reported NOAEL =375 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 129-17-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acid Blue 1 is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Chemistry & Identifiers
IUPAC Name
sodium 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,3-disulfonate
InChIKey
SJEYSFABYSGQBG-UHFFFAOYSA-M
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
FDA Import Alert 53-06 explicitly flags CI 42045 as non-permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Blue 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Acid Blue 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =375 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
16, Sup 7
Evaluation Year
1987
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1355
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1355
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | Cosmetics except near eyes (Class 3) |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
Blue VRS | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Acid Blue 1.
Regulatory Flags
potential-allergen
colorant
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Blue 1 by CAS number or substance name.
Studies
2
Lowest NOAEL
375 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
C.I. Food Blue 3
Patent Blue VF
Patent Blue Violet
C.I. Acid Blue 1, sodium salt
C.I. Acid Blue 1
Acid Blue V
Acid bright azure Z
Acid Brilliant Blue Z
Acid Brilliant Blue VF
Acid Brilliant Sky Blue Z
Acid Leather Blue V
Aizen Brilliant Acid Pure Blue VH
Alphazurine 2G
Amacid Blue V
Anhydro-4,4'-bis(diethylamino)triphenylmethanol-2',4''-disulphonic acid, monosodium salt
Blue URS
Blue VRS
Brilliant Acid Blue A Export
Brilliant Acid Blue V Extra
Chemical Function
Dye
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
banned; Europe; Personal care
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1731183
Frequently Asked Questions
Is Acid Blue 1 allowed in the EU?
Acid Blue 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Blue 1 do in cosmetics?
Acid Blue 1 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 129-17-9.
What is the NOAEL for Acid Blue 1?
The NOAEL (No Observed Adverse Effect Level) for Acid Blue 1 is =375 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acid Blue 1 used outside cosmetics?
Acid Blue 1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acid Blue 1 have different safety status in cosmetics vs industrial chemicals?
Acid Blue 1 is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Acid Blue 1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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