Excellent Cosmetic Ingredient NOAEL Data GHS Classified

CI 77220

CAS Number
471-34-1
Function
Colorant (white opacifier), Bulking agent, Abrasive
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not separately listed as an FDA color additive; generally used as a cosmetic ingredient (not as a color additive per FDA definition)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for CI 77220. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3000 mg/kg bw/day oral mouse Reproductive COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1015 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 9989 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1349 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 385 mg/kg bw/day oral rat Developmental COSMOS_DB
dose_tested 1015 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL >1000 mg/kg bw/day oral - oral REACH
NOAEL >1000 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Hazard Statements
No hazard classification according to GHS criteria
Short-term Exposure Effects
May cause mechanical irritation to the respiratory tract and eyes.
Long-term Exposure Effects
Health effects of the substance have been investigated but none have been found

Expert Verdict

Permitted colorant and bulking agent with excellent safety profile; ensure heavy metal impurity specifications are met as standard for mineral-origin ingredients.

⚠️
Concern Level: Low

Regulatory Flags

colorant eu_children_restricted epa_safer_alternative fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is CI 77220 safe in cosmetics?

Permitted colorant and bulking agent with excellent safety profile; ensure heavy metal impurity specifications are met as standard for mineral-origin ingredients. The EU classifies CI 77220 as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is CI 77220 allowed in the EU?

CI 77220 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 77220 do in cosmetics?

CI 77220 functions as: Colorant (white opacifier), Bulking agent, Abrasive. It is classified as a cosmetic ingredient in our database. CAS number: 471-34-1.

What is the Margin of Safety for CI 77220?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 77220?

The NOAEL (No Observed Adverse Effect Level) for CI 77220 is 3000 mg/kg bw/day based on a Reproductive study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check CI 77220 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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