cis-3-Hexenyl Butyrate

INCI: CIS-3-HEXENYL BUTYRATE

CAS Number
16491-36-4
Function
Fragrance ingredient (fruity, green, wine-like, brandy-like)
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA GRAS; RIFM safety assessed and cleared across all 7 human health endpoints

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Screening-level PEC/PNEC initially >1, but refined to <1 with measured biodegradation data (77% in 28 days, OECD 301F); IFRA max use levels range from 0.023% (axillae) to no restriction (non-skin-contact air care)

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is cis-3-Hexenyl Butyrate safe in cosmetics?

Screening-level PEC/PNEC initially >1, but refined to <1 with measured biodegradation data (77% in 28 days, OECD 301F); IFRA max use levels range from 0.023% (axillae) to no restriction (non-skin-contact air care) The EU classifies cis-3-Hexenyl Butyrate as "permitted". Safety rating: EXCELLENT.

Is cis-3-Hexenyl Butyrate allowed in the EU?

cis-3-Hexenyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does cis-3-Hexenyl Butyrate do in cosmetics?

cis-3-Hexenyl Butyrate functions as: Fragrance ingredient (fruity, green, wine-like, brandy-like). It is classified as a cosmetic ingredient in our database. CAS number: 16491-36-4.

What is the Margin of Safety for cis-3-Hexenyl Butyrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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