Is cis-3-Hexenyl Butyrate safe in cosmetics?
cis-3-Hexenyl Butyrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
cis-3-Hexenyl Butyrate
Also known as: cis-Butyric acid, 3-hexenyl ester, Butyric acid, 3-hexenyl ester, (Z)-, EINECS 240-553-7, FEMA No. 3402, 3-Hexenyl butanoate, cis- (+6 more)
INCI: CIS-3-HEXENYL BUTYRATE
cis-3-Hexenyl Butyrate (CAS 16491-36-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (fruity, green, wine-like, brandy-like). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 16491-36-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (fruity, green, wine-like, brandy-like)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] butanoate
InChIKey
ZCHOPXVYTWUHDS-WAYWQWQTSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS; RIFM safety assessed and cleared across all 7 human health endpoints
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
157
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXENYL BUTYRATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Butyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
cis-Butyric acid, 3-hexenyl ester
Butyric acid, 3-hexenyl ester, (Z)-
EINECS 240-553-7
FEMA No. 3402
3-Hexenyl butanoate, cis-
3-Hexenyl butanoate, (Z)-
beta,gamma-Hexenyl butyrate
3-Hexenyl butyrate, (Z)-
cis-3-Hexen-1-yl butyrate
(Z)-3-Hexenyl butyrate
UNII-O47B839622
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CIS-3-HEXENYL BUTYRATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl Butyrate allowed in the EU?
cis-3-Hexenyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Butyrate do in cosmetics?
cis-3-Hexenyl Butyrate functions as: Fragrance ingredient (fruity, green, wine-like, brandy-like). It is classified as a cosmetic ingredient in our database. CAS number: 16491-36-4.
Is cis-3-Hexenyl Butyrate used outside cosmetics?
cis-3-Hexenyl Butyrate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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