Poor Cosmetic Ingredient

Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract

INCI: CORNYEABACTERIUM LIPOPHILICUS/PRASTERONE FERMENT FILTRATE EXTRACT

CAS Number
Not assigned
Function
Skin conditioning (ferment-derived bioactive)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes FDA: MAJOR FLAG — Prasterone (DHEA) is a controlled drug ingredient in the US (FDA-approved as Intrarosa). Use in cosmetics would likely be challenged as adulteration under FD&C Act.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL: Prasterone is DHEA, an endocrine-active substance. Even as a ferment filtrate, the presence of DHEA metabolites raises serious regulatory red flags. EU regulators would likely challenge endocrine safety despite not being Annex II-listed. US: essentially unusable as FDA considers DHEA a drug. Do not use without extensive regulatory counsel.

⚠️
Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract safe in cosmetics?

CRITICAL: Prasterone is DHEA, an endocrine-active substance. Even as a ferment filtrate, the presence of DHEA metabolites raises serious regulatory red flags. EU regulators would likely challenge endocrine safety despite not being Annex II-listed. US: essentially unusable as FDA considers DHEA a drug. Do not use without extensive regulatory counsel. The EU classifies Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract as "restricted". Safety rating: POOR.

Is Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract allowed in the EU?

Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract do in cosmetics?

Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract functions as: Skin conditioning (ferment-derived bioactive). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Cornyeabacterium Lipophilicus/Prasterone Ferment Filtrate Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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