Is Decapeptide-12 safe in cosmetics?
Decapeptide-12 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Decapeptide-12
INCI: DECAPEPTIDE-12
Decapeptide-12 (CAS 137665-91-9) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 137665-91-9 →
Auto-generated CPSR Part A draft with source citations
Function
Peptide / Anti-aging active
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
regarding this peptide.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Decapeptide-12.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, dark-spot-reduction", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, In…
peptide
{"cas_number": "935288-50-9", "trade_name": "Lumixyl / Melanostatin DM", "peptide_sequence_amino_acids": "Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr", "peptide_length_residues": "10", "molecular_weight_daltons": "1349.5", "peptide_class": "enzyme_inhibitor", "mechanism_of_action": "Tyrosinase inhibitor, reduces melanin production", "target_protein_or_receptor": "Tyrosinase", "collagen_boost_pct_in_vi…
self_tanning
{"cas_number": "proprietary", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "…
skin_brightening
{"cas_number": "823202-99-9", "mechanism_of_action": "Tyrosinase downregulation; MITF modulation", "melanogenesis_pathway_target": "MITF; tyrosinase expression", "tyrosinase_inhibition_ic50_um": "Transcription level", "tyrosinase_inhibition_vs_kojic_acid": "Gene expression", "melanosome_transfer_inhibitor": "No", "melanin_oxidation_reducer": "Partial", "endothelin_pathway_blocker": "No", "alpha_ms…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Decapeptide-12.
Frequently Asked Questions
Is Decapeptide-12 allowed in the EU?
Decapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Decapeptide-12 do in cosmetics?
Decapeptide-12 functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 137665-91-9.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Skin Conditioning
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