Excellent Cosmetic Ingredient GHS Classified SCCS/CIR Reviewed

Diacetone Alcohol

Also known as: 4-Hydroxy-4-methyl-2-pentanone, 4-01-00-04023, BRN 1740440, Caswell No. 280, Diacetone (+13 more)

INCI: DIACETONE ALCOHOL

Diacetone Alcohol (CAS 123-42-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, solvent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 4 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 123-42-2 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Diacetone Alcohol is classified GHS Danger (H226, H319, H335, H361d, H227, H315, H336, H361) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

123-42-2

View industrial chemical safety profile →

Function

Fragrance ingredient, solvent

Safety Rating

EXCELLENT

Chemistry & Identifiers

Formula

C6H12O2

116.16 g/mol

EC Number

204-626-7

PubChem CID

31256

IUPAC Name

4-hydroxy-4-methylpentan-2-one

InChIKey

SWXVUIWOUIDPGS-UHFFFAOYSA-N

ChEBI: CHEBI:55381 UNII: Q7WP157PTD Wikidata: Q421486

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes Permitted — CIR Expert Panel concluded safe in present practices of use and concentration

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diacetone Alcohol.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure far above the OEL could cause lowering of consciousness.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir

Verdict: safe

NOAEL: 100 mg/kg/d (inhalation)

ailable data and concluded that Diacetone Alcohol is safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics, Diacetone Alcohol Introduction This

cir

Verdict: safe

NOAEL: 1000 mg/kg/d (not specified)

cir

Verdict: safe

NOAEL: 1000 mg/kg/ d (not specified)

cir

Verdict: safe

NOAEL: 1000 mg/kg bw/d (not specified)

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Diacetone Alcohol across SCCS product categories, with measured dermal absorption where available.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Warning

Pictograms

Harmful / Irritant

Hazard Class and Category

Eye Irrit. 2

Hazard Statements

H319 Causes serious eye irritation

Specific Concentration Limits / M-factors

Eye Irrit. 2; H319: C ≥ 10.0%

Inserted via ATP: CLP00

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

10,000 - 100,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)

ICSC Safety Card

0647

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Skin Eye Respiratory Irritation

... Eye, nose, & throat /irritation occurs/ in most human subjects exposed to 100 ppm for 15 min ... . | Liquid irritating to skin & eyes.

Source: Hazardous Substances Data Bank (HSDB)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Deodorizer Flavouring and nutrient Fragrance Solvent

Regulatory List Membership (1)

FDA Indirect Food Contact Additives

Expert Verdict

Expert safety assessment and concern-level summary for Diacetone Alcohol.

Regulatory Flags

fragrance-component

Known Synonyms

4-Hydroxy-4-methyl-2-pentanone 4-01-00-04023 BRN 1740440 Caswell No. 280 Diacetone Diacetonyl alcohol EINECS 204-626-7 EPA Pesticide Chemical Code 033901 4-Hydroxy-4-methyl pentan-2-one 4-Hydroxy-4-methylpentanone-2 Pyranton 4-Hydroxy-4-methyl-pentan-2-on 4-Idrossi-4-metil-pentan-2-one Diacetonalcohol Diacetonalcool UNII-Q7WP157PTD Diacetone-alcool Dimethyl acetonyl carbinol

Chemical Function

Solvent Deodorizer Fragrance Flavouring and nutrient

Regulatory Lists

artificial_saliva; detected; emissions; Europe; Toys and children's products artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods Cleaning products and household care - shoes; Europe Cleaning products and household care - shoes; Europe Europe air; Cons electronics mech appliances and machinery; detected; emissions; Europe inert_ingredient; non_food_use; Pesticides Indirect additives food contact (10/2018)

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID

CHEMBL3182048

View full pharmaceutical profile →

Frequently Asked Questions

Is Diacetone Alcohol safe in cosmetics?

Diacetone Alcohol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.

Is Diacetone Alcohol allowed in the EU?

Diacetone Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diacetone Alcohol do in cosmetics?

Diacetone Alcohol functions as: Fragrance ingredient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 123-42-2.

Is Diacetone Alcohol used outside cosmetics?

Diacetone Alcohol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Diacetone Alcohol have different safety status in cosmetics vs industrial chemicals?

Diacetone Alcohol is classified GHS Danger (H226, H319, H335, H361d, H227, H315, H336, H361) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

Check Diacetone Alcohol compliance across multiple jurisdictions:

Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

Substance Compliance

Check compliance across multiple jurisdictions

MoS Calculator

Calculate Margin of Safety using SCCS methodology

Heavy Metal Limits

Compare limits across jurisdictions

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