Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diethyl Ethanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 125 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 440 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Primary concern: Nitrosamine formation potential—must test finished product for N-nitrosodiethanolamine (NDELA) or related nitrosamines. Skin and eye irritant, corrosive at high concentrations. Classified GHS: H302, H312, H332, H311, H314. Requires strict use-level control.
Regulatory Flags
Frequently Asked Questions
Is Diethyl Ethanolamine safe in cosmetics?
Primary concern: Nitrosamine formation potential—must test finished product for N-nitrosodiethanolamine (NDELA) or related nitrosamines. Skin and eye irritant, corrosive at high concentrations. Classified GHS: H302, H312, H332, H311, H314. Requires strict use-level control. The EU classifies Diethyl Ethanolamine as "prohibited". Safety rating: POOR. 5 toxicological study endpoint(s) are available in our database.
Is Diethyl Ethanolamine allowed in the EU?
Diethyl Ethanolamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Ethanolamine do in cosmetics?
Diethyl Ethanolamine functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 100-37-8.
What is the Margin of Safety for Diethyl Ethanolamine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Ethanolamine?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Ethanolamine is 125 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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