Excellent Cosmetic Ingredient NOAEL Data

Diethylhexyl Dimer Dilinoleate

INCI: DIETHYLHEXYL DIMER DILINOLEATE

CAS Number
110675-26-8
Function
Skin-conditioning agent — emollient
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted. CIR Expert Panel concluded safe in present practices of use and concentration.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Diethylhexyl Dimer Dilinoleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOEL 1000 other oral rat oral REACH
NOEL 10 mg/kg bw/day oral dog oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

CIR Expert Panel deemed safe at current use concentrations; highest tested irritation/sensitization concentration was 27%, though lipstick applications may reach 53%.

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Diethylhexyl Dimer Dilinoleate safe in cosmetics?

CIR Expert Panel deemed safe at current use concentrations; highest tested irritation/sensitization concentration was 27%, though lipstick applications may reach 53%. The EU classifies Diethylhexyl Dimer Dilinoleate as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.

Is Diethylhexyl Dimer Dilinoleate allowed in the EU?

Diethylhexyl Dimer Dilinoleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylhexyl Dimer Dilinoleate do in cosmetics?

Diethylhexyl Dimer Dilinoleate functions as: Skin-conditioning agent — emollient. It is classified as a cosmetic ingredient in our database. CAS number: 110675-26-8.

What is the Margin of Safety for Diethylhexyl Dimer Dilinoleate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diethylhexyl Dimer Dilinoleate?

The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Dimer Dilinoleate is 1000 other based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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