Is Dimethicone Crosspolymer safe in cosmetics?
Dimethicone Crosspolymer has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Dimethicone Crosspolymer
Also known as: Dow Corning 365 Dimethicone NF Emulsion, Dimeticone, Dow Corning 5-7139, Gransil 530, Silicone Fluid 350 (+3 more)
INCI: DIMETHICONE CROSSPOLYMER
Dimethicone Crosspolymer (CAS 9006-65-9) is a cosmetic emollient functioning as film-forming, texture modifier, matte finish agent. Reported NOAEL =0.2 mg/kg bw/day (WHO/JECFA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
Function
film-forming, texture modifier, matte finish agent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: safe in cosmetics; silicone elastomer providing soft-focus velvety matte finish by absorbing surface oils and scattering light; no FDA restrictions; used in matte lipsticks to achieve optical matte effect without full occlusive removal
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethicone Crosspolymer.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dimethicone Crosspolymer. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.2 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =0.2 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =0.2 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =4.28571428571429 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =4.28571428571429 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =4.28571428571429 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =30 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =30 mg/kg bw/day | - | - | Toxicology study | WHO/JECFA |
| NOAEL | =246 mg/kg bw/day | - | - | Subchronic toxicity | WHO/JECFA |
| NOAEL | =246 mg/kg bw/day | - | - | Subchronic toxicity | WHO/JECFA |
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >20000 mg/kg | Mouse | oral | - | ChemIDplus |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-stain agent
Chemical reaction regulator
Defoamer
Emulsifier
Film former
Humectant
Lubricating agent
Processing aids not otherwise specified
Softener and conditioner
Stabilizing agent
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
Editorial summary
Preliminary editorial summary for Dimethicone Crosspolymer — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cir-approved
lip-safe
silicone-elastomer
matte-finish
texture-modifier
soft-focus
oral-safe
inert-polymer
no-eu-restriction
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethicone Crosspolymer by CAS number or substance name.
Studies
16
Lowest NOAEL
0.2 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
WHO/JECFA
Known Synonyms
Dow Corning 365 Dimethicone NF Emulsion
Dimeticone
Dow Corning 5-7139
Gransil 530
Silicone Fluid 350
Polydimethyl siloxane
DIMETHICONE 350
EC No.: 618-433-4
Chemical Function
Defoamer
Lubricating agent
Softener and conditioner
Humectant
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - general moisturizing - hand/body lotion
Europe; Personal care - hair styling and care - shampoo-dandruff
consumer_product; Europe
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
Cleaning products and household care; Europe
Cleaning products and household care; Europe
Europe; Personal care - oral and dental care - teeth whitener
Europe; Personal care - make-up and related
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
dimethicone
ChEMBL ID
CHEMBL1200838
Adverse Event Associations
2534
Frequently Asked Questions
Is Dimethicone Crosspolymer allowed in the EU?
Dimethicone Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethicone Crosspolymer do in cosmetics?
Dimethicone Crosspolymer functions as: film-forming, texture modifier, matte finish agent. It is classified as a Emollient in our database. CAS number: 9006-65-9.
What is the NOAEL for Dimethicone Crosspolymer?
The NOAEL (No Observed Adverse Effect Level) for Dimethicone Crosspolymer is =0.2 mg/kg bw/day based on a Toxicology study study via oral route in rat. A total of 10 study endpoints are available. Source: WHO/JECFA.
Is Dimethicone Crosspolymer used outside cosmetics?
Dimethicone Crosspolymer also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dimethicone Crosspolymer compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Alkyl Benzoate
EXCELLENT
Same category
Emollient; skin-conditioning agent; U...
Argania Spinosa Kernel Oil
EXCELLENT
Same category
Plant-derived emollient oil from arga...
Babassu Oil
EXCELLENT
Same category
Skin Conditioning - Emollient: Soften...
Babassu Oil
EXCELLENT
Same category
Emollient; lauric acid-rich tropical oil
Beeswax
EXCELLENT
Same category
Wax; viscosity modifier; film-former
Behenic Acid
EXCELLENT
Same category
Cleansing, Emulsifier, Opacifier, Sur...
1-Methylhydantoin-2-imide (Creatinine)
EXCELLENT
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
EXCELLENT
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Antioxidant; tyrosinase inhibitor; me...
Albumen
MODERATE
Chemical family
Skin conditioning, film forming
Albumen Extract
MODERATE
Chemical family
Skin conditioning
Dimethicone
EXCELLENT
Chemical family
emollient, skin-conditioning, film-fo...
Is Dimethicone Crosspolymer in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dimethicone Crosspolymer in your formulation.