Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dimethicone Crosspolymer. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 1250 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 1250 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 1250 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Crosslinked silicone elastomer creating soft-focus optical matte finish in lip products by absorbing surface oils and scattering light. Provides velvet texture without the full drying effect of alternative matte systems. CIR confirms safety with no allergenicity concerns. Biologically inert with negligible absorption; oral ingestion from lip products is safe as crosslinked silicone passes through GI tract without systemic absorption. No regulatory restrictions.
Regulatory Flags
Frequently Asked Questions
Is Dimethicone Crosspolymer safe in cosmetics?
Crosslinked silicone elastomer creating soft-focus optical matte finish in lip products by absorbing surface oils and scattering light. Provides velvet texture without the full drying effect of alternative matte systems. CIR confirms safety with no allergenicity concerns. Biologically inert with negligible absorption; oral ingestion from lip products is safe as crosslinked silicone passes through GI tract without systemic absorption. No regulatory restrictions. The EU classifies Dimethicone Crosspolymer as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Dimethicone Crosspolymer allowed in the EU?
Dimethicone Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethicone Crosspolymer do in cosmetics?
Dimethicone Crosspolymer functions as: film-forming, texture modifier, matte finish agent. It is classified as a Emollient in our database. CAS number: 9006-65-9.
What is the Margin of Safety for Dimethicone Crosspolymer?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethicone Crosspolymer?
The NOAEL (No Observed Adverse Effect Level) for Dimethicone Crosspolymer is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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